Effects of Dietary Selenium on Histopathological Changes and T Cells of Spleen in Broilers Exposed to Aflatoxin B 1

Kejie Chen, Xi Peng, Jing Fang, Hengmin Cui, Zhicai Zuo, Junliang Deng, Zhengli Chen, Yi Geng, Weimin Lai, Li Tang and Qingqiu Yang
Additional contact information
Kejie Chen: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Xi Peng: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Jing Fang: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Hengmin Cui: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Zhicai Zuo: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Junliang Deng: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Zhengli Chen: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Yi Geng: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Weimin Lai: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Li Tang: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Qingqiu Yang: Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China

IJERPH, 2014, vol. 11, issue 2, 1-10

Abstract: Aflatoxin B 1 (AFB 1 ), which causes hepatocellular carcinoma and immune-suppression, is commonly found in feedstuffs. To evaluate the ability of selenium (Se) to counteract the deleterious effects of AFB 1 , two hundred 1-day-old male avian broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB 1 (AFB 1 group), 0.3 mg/kg AFB 1 +0.2 mg/kg Se (+Se group I), 0.3 mg/kg AFB 1 +0.4 mg/kg Se (+Se group II) and 0.3 mg/kg AFB 1 +0.6 mg/kg Se (+Se group III), respectively. Compared with control group, the relative weight of spleen in the AFB 1 group was decreased at 21 days of age. The relative weight of spleen in the three +Se groups was higher than that in the AFB 1 group. By pathological observation, the major spleen lesions included congestion in red pulp and vacuoles appeared in the lymphatic nodules and periarterial lymphatic sheath in the AFB 1 group. In +Se groups II and III, the incidence of major splenic lesions was decreased. The percentages of CD 3 + , CD 3 + CD 4 + and CD 3 + CD 8 + T cells in the AFB 1 group were lower than those in control group from 7 to 21 days of age, while there was a marked increase in the three +Se groups compared to the AFB 1 group. The results indicated that sodium selenite could improve the cellular immune function impaired by AFB 1 through increasing the relative weight of spleen and percentages of splenic T cell subsets, and alleviating histopathological spleen damage.

Keywords: sodium selenite; aflatoxin b 1; histological lesion; T-cell subsets; flow cytometry; broilers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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