Hematological and Biochemical Data Obtained in Rural Northern Uganda

Nirianne M. Q. Palacpac, Edward Ntege, Betty Balikagala, Adoke Yeka, Hiroki Shirai, Nahoko Suzuki, Christopher Nsereko, Bernard N. Kanoi, Takuya Okada, Thomas G. Egwang and Toshihiro Horii
Additional contact information
Nirianne M. Q. Palacpac: Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan
Edward Ntege: Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda
Betty Balikagala: Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda
Adoke Yeka: Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda
Hiroki Shirai: The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-cho, Kanonji, Kagawa 768-0061, Japan
Nahoko Suzuki: The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-cho, Kanonji, Kagawa 768-0061, Japan
Christopher Nsereko: Lira Medical Center, Lira, Uganda
Bernard N. Kanoi: Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda
Takuya Okada: The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-cho, Kanonji, Kagawa 768-0061, Japan
Thomas G. Egwang: Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda
Toshihiro Horii: Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan

IJERPH, 2014, vol. 11, issue 5, 1-16

Abstract: Reference intervals for common hematological and clinical chemistry parameters constitute an important basis for health care. Moreover, with increasing priority in drug and vaccine development for infectious diseases in Africa, the first priority is the safety evaluation and tolerability of the candidate interventions in healthy populations. To accurately assess health status and address adverse events, clinical reference intervals in the target population are necessary. We report on hematological and biochemical indices from healthy volunteers who participated in a clinical trial in Lira, northern Uganda. Median and nonparametric 95% percentiles on five hematology and 15 biochemistry analytes are shown. Although most hematological analytes conformed to reported reference intervals and trends in Africa, literature review from different African countries highlight the need for a region-specific children reference interval that can be appropriate for the population.

Keywords: reference intervals; clinical trials; hematology; biochemistry; adult reference values; children reference values (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
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