Perchlorate Exposure and Thyroid Function in Ammonium Perchlorate Workers in Yicheng, China

Hongxia Chen, Libing Wu, Xia Wang, Qin Liu, Miaohong Ding, Kailiang Peng and Zhongji Meng
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Hongxia Chen: Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
Libing Wu: Department of Nuclear Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
Xia Wang: Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, China
Qin Liu: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Miaohong Ding: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Kailiang Peng: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zhongji Meng: Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

IJERPH, 2014, vol. 11, issue 5, 1-13

Abstract: The impact of low level dust on the thyroid function of workers chronically exposed to ammonium perchlorate (AP) is uncertain and controversial. The aim of this study was to examine whether workers in China with long-term (>3 years) occupational exposure to low levels of AP dust had affected thyroid homeostasis. Mean occupational exposures to AP dust ranged from 0.43 to 1.17 mg/m 3 . Geometric means of post-shift urinary perchlorate levels were 20.5 µg/L for those exposed and 12.8 µg/L for the controls. No significant differences were found for thyroid function parameters of FT 3 , FT 4 , or log TSH or for TPO prevalence or thyroglobulin levels. Additionally, no differences in findings were observed for complete blood count (CBC), serum biochemical profile, or pulmonary function test. Median urinary iodine levels of 172 and 184 µg/L showed that the workers had sufficient iodine intake. This study found no effect on thyroid function from long term, low-level documented exposure to ammonium perchlorate. It is the first study to report both thyroid status parameters and urinary perchlorate, a biomarker of internal perchlorate exposure, in occupationally exposed workers in China.

Keywords: ammonium perchlorate; thyroid; occupational exposure; biomarker (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
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