Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality

Chung-Yen Lu, Yee-Chung Ma, Pei-Chun Chen, Chin-Ching Wu and Yi-Chun Chen
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Chung-Yen Lu: School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 404, Taiwan
Yee-Chung Ma: Institute of Environmental Health, National Taiwan University, Taipei 100, Taiwan
Pei-Chun Chen: Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 100, Taiwan
Chin-Ching Wu: Department of Public Health, China Medical University, Taichung 404, Taiwan
Yi-Chun Chen: Department of Health Management, I-Shou University, Kaohsiung 824, Taiwan

IJERPH, 2014, vol. 11, issue 6, 1-12

Abstract: Studies have used 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker to detect systemic oxidative DNA damage associated with oxidative stress. However, studies on the association between exposure to tobacco smoking and urinary 8-OHdgG give inconsistent results. Limited studies have estimated the oxidative stress among office workers. This study assessed the association between urinary 8-OHdG and cotinine for office workers. Workers (389) including smokers, ex-smokers and non-smokers from 87 offices at high-rise buildings in Taipei participated in this study with informed consent. Each participant completed a questionnaire and provided a spot urine specimen at the end of work day for measuring urinary 8-OHdG and cotinine. The carbon dioxide (CO 2 ) levels in workers’ offices were also measured. The questionnaire reported socio-demographic characteristics, life styles and allergic history. The urinary 8-OHdG level increased with the cotinine level among participants (Spearmans’ rho = 0.543, p < 0.001). The mean of urinary 8-OHdG and cotinine was 5.81 ± 3.53 ?g/g creatinine and 3.76 ± 4.06 ?g/g creatinine, respectively. Comparing with non-smokers, the adjusted odds ratio (OR) of having urinary 8-OHdG greater than the median level of 4.99 ?g/g creatinine was 5.30 (95% confidence intervals (CI) = 1.30–21.5) for current smokers and 0.91 (95% CI = 0.34–2.43) for former smokers. We also found workers exposed to 1,000 ppm of CO 2 at offices had an adjusted OR of 4.28 (95% CI = 1.12–16.4) to have urinary 8-OHdG greater than 4.99 ?g/g creatinine, compared to those exposed to indoor CO 2 under 600 ppm. In conclusion, urinary 8-OHdG could represent a suitable marker for measuring smoking and CO 2 exposure for office workers.

Keywords: carbon dioxide; cotinine; 8-hydroxydeoxyguanosine; office worker; tobacco smoking (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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