Differences of Urinary Arsenic Metabolites and Methylation Capacity between Individuals with and without Skin Lesions in Inner Mongolia, Northern China

Qiang Zhang, Yongfang Li, Juan Liu, Da Wang, Quanmei Zheng and Guifan Sun
Additional contact information
Qiang Zhang: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China
Yongfang Li: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China
Juan Liu: Library of Tianjin Medical University, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China
Da Wang: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China
Quanmei Zheng: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China
Guifan Sun: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China

IJERPH, 2014, vol. 11, issue 7, 1-14

Abstract: Incomplete arsenic (As) methylation has been considered a risk factor of As-related diseases. This study aimed to examine the difference of urinary As metabolites and the methylation capacity between subjects with and without skin lesions. Urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were analyzed. The percentage of each As species (iAs%, MMA%, and DMA%), the primary methylation index (PMI) and secondary methylation index (SMI) were calculated. The results showed that subjects with skin lesions have higher levels of urinary iAs (99.08 vs. 70.63 ?g/g Cr, p = 0.006) and MMA (69.34 vs. 42.85 ?g/g Cr, p = 0.016) than subjects without skin lesions after adjustment for several confounders. Significant differences of urianry MMA% (15.49 vs. 12.11, p = 0.036) and SMI (0.74 vs. 0.81, p = 0.025) were found between the two groups. The findings of the present study suggest that subjects with skin lesions may have a lower As methylation capacity than subjects without skin lesions.

Keywords: arsenic; groundwater; skin lesion; methylation capacity; metabolism (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
References: View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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