Negative Correlation of Serum Adiponectin Level with Aortic Stiffness in Elderly Diabetic Persons

Jui-Jung Hung, Du-An Wu, Ming-Chun Chen and Bang-Gee Hsu
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Jui-Jung Hung: School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
Du-An Wu: School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
Ming-Chun Chen: School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
Bang-Gee Hsu: School of Medicine, Tzu Chi University, Hualien 97004, Taiwan

IJERPH, 2022, vol. 19, issue 5, 1-11

Abstract: Adiponectin has anti-inflammatory activity against atherosclerosis. Aortic stiffness is a common manifestation of atherosclerosis in diabetes mellitus and elderly persons. This study aimed to evaluate whether low serum adiponectin levels were associated with aortic stiffness in geriatric diabetic patients. Blood samples were obtained from 130 diabetic participants aged ≥ 65 years. We defined high aortic stiffness based on a carotid–femoral pulse wave velocity (cfPWV) of >10 m/s. Circulating adiponectin concentrations were examined using enzyme-linked immunosorbent assays. Sixty-six participants (50.8%) had aortic stiffness. Patients with aortic stiffness had lower serum adiponectin concentrations than those in the control group ( p < 0.001). Multivariate logistic regression analysis showed that the adiponectin level (odds ratio: 0.939, 95% confidence interval: 0.898–0.981, p = 0.005) was an independent predictor of aortic stiffness in elderly diabetic persons. Multivariate forward stepwise linear regression analysis also demonstrated that the adiponectin level (β = −0.256, adjusted R 2 change = 0.100, p = 0.003) was negatively associated with cfPWV values in older diabetic patients. In conclusion, serum adiponectin is negatively correlated with cfPWV and is an independent predictor of aortic stiffness in elderly diabetic persons.

Keywords: adiponectin; aging; aortic stiffness; diabetes mellitus; carotid–femoral pulse wave velocity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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