Blood Chemo-Profiling in Workers Exposed to Occupational Pyrethroid Pesticides

Ohoud O. Sufyani, Magbool E. Oraiby, Ibraheem M. Attafi (), Elsiddig Noureldin, Ommer Dafallah, Yahya A. Hobani, Sultan Qumayi, Ahmad Sahly, Yasser Majrabi, Ali Maashi, Abdulaziz A. Almane, Zaki M. Eisa, Abdullah Alaamri, Waheed Mohammed, Ahmed M. Hakami, Mohammed A. Attafi, Ibrahim A. Khardali, Ala’udin Hakami, Ebraheem Alkhyat and Mari H. Alnashri
Additional contact information
Ohoud O. Sufyani: Central Blood Bank, Jazan Health Cluster, Jazan 45142, Saudi Arabia
Magbool E. Oraiby: Forensic Toxicology Services, Ministry of Health Branch in Jazan region, Jazan 45142, Saudi Arabia
Ibraheem M. Attafi: South Al-Qunfudah General Hospital, Makkah Health Cluster, Makkah 21912, Saudi Arabia
Elsiddig Noureldin: Weqaa Center Laboratories, Division of Disease Vectors, Jazan 45142, Saudi Arabia
Ommer Dafallah: Weqaa Center Laboratories, Division of Disease Vectors, Jazan 45142, Saudi Arabia
Yahya A. Hobani: Executive Management of Community and Public Health, Jazan Health Cluster, Jazan 45142, Saudi Arabia
Sultan Qumayi: Jazan Health Cluster, Jazan 45142, Saudi Arabia
Ahmad Sahly: Jazan Health Cluster, Jazan 45142, Saudi Arabia
Yasser Majrabi: Jazan Health Cluster, Jazan 45142, Saudi Arabia
Ali Maashi: Jazan Health Cluster, Jazan 45142, Saudi Arabia
Abdulaziz A. Almane: Weqaa Center Laboratories, Division of Disease Vectors, Jazan 45142, Saudi Arabia
Zaki M. Eisa: Public Health Authority, Jazan 45142, Saudi Arabia
Abdullah Alaamri: Public Health Authority, Jazan 45142, Saudi Arabia
Waheed Mohammed: Public Health Authority, Jazan 45142, Saudi Arabia
Ahmed M. Hakami: Forensic Toxicology Services, Ministry of Health Branch in Jazan region, Jazan 45142, Saudi Arabia
Mohammed A. Attafi: Forensic Toxicology Services, Ministry of Health Branch in Jazan region, Jazan 45142, Saudi Arabia
Ibrahim A. Khardali: Forensic Toxicology Services, Ministry of Health Branch in Jazan region, Jazan 45142, Saudi Arabia
Ala’udin Hakami: Jazan Municipality, Jazan 45142, Saudi Arabia
Ebraheem Alkhyat: Jazan Municipality, Jazan 45142, Saudi Arabia
Mari H. Alnashri: South Al-Qunfudah General Hospital, Makkah Health Cluster, Makkah 21912, Saudi Arabia

IJERPH, 2025, vol. 22, issue 5, 1-17

Abstract: This study investigates the effect of occupational exposure to pyrethroid insecticides on the blood chemo-profiles of workers in the Jazan region. This study was conducted to examine this issue, and workers were divided into exposure groups based on how long they had been employed—from one to two years to more than eight years. Blood samples were analyzed to determine their hematological and biochemical parameters, and their chemo-profiles were assessed by GCMS analysis. Workers exposed for 8+ years had a 3.7 times higher risk of chronic diseases than those exposed for 1–2 years ( p < 0.01). Prolonged exposure to pyrethroid pesticides at work is linked to significant changes in blood chemical profiles. While gamma-glutamyl transferase (GGT) levels ( p < 0.05) were rather increased by extended exposure times, albumin levels ( p < 0.05) showed a significant decrease. These findings suggest re-evaluating and improving workplace safety practices to protect workers from extended pyrethroid exposure.

Keywords: workplace exposure; insecticide; metabolic biomarkers; GCMS analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2025
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