Itaconic Acid and Its Applications for Textile, Pharma and Agro-Industrial Purposes

Nisha Devi, Shubhangi Singh, Shivakumar Manickam, Natália Cruz-Martins (), Vinod Kumar, Rachna Verma and Dinesh Kumar ()
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Nisha Devi: School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India
Shubhangi Singh: School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India
Shivakumar Manickam: Petroleum and Chemical Engineering Department, Faculty of Engineering, University Teknologi Brunei, Bandar Seri Begawan BE1410, Brunei
Natália Cruz-Martins: Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Vinod Kumar: School of Water, Energy and Environment, Cranfield University, Cranfield MK43 0KL, UK
Rachna Verma: School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India
Dinesh Kumar: School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India

Sustainability, 2022, vol. 14, issue 21, 1-24

Abstract: Itaconic acid (IA) is a well-known bio-based monounsaturated organic acid (C 5 H 6 O 4 ), with a white color and crystalline structure. It is widely used in the agro-based, plastics, textile, paint and pharmaceutical sectors, owing to its flexible structure, due to the presence of functional groups with covalent double bonds. IA is an alternative to the petrochemicals acrylic and methacrylic acids. Commercial manufacturing of IA using Aspergillus terreus is more economically effective and feasible, and the Department of Energy (DOE) of the United States added IA under the “top 12” organic chemicals in 2004. This review provides an overview on the synthesis of IA and improvement of its yield by mutagenesis and metabolic engineering of Aspergillus and other fungal strains, along with its wide applications for food, pharmaceutical and textile purposes.

Keywords: itaconic acid; metabolic engineering; Aspergillus terreus; market scenario (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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