Three-dimensional Radiologic Assessment of Chemotherapy Response in ă Ewing Sarcoma Can Be Used to Predict Clinical Outcome

Maryam Aghighi, Justin Boe, Jarrett Rosenberg, Rie von Eyben, Rakhee S. Gawande, Philippe Petit (), Tarsheen K. Sethi, Jeremy Sharib, Neyssa M. Marina, Steven G. Dubois and Heike E. Daldrup-Link
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Philippe Petit: Radiologie pédiatrique et prénatale [Hôpital de la Timone - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM]

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Abstract: Purpose: To compare the agreement of three-dimensional (3D) tumor ă measurements for therapeutic response assessment of Ewing sarcoma ă according to the Children's Oncology Group (COG) criteria, ă one-dimensional (1D) Response Evaluation Criteria in Solid Tumors ă (RECIST), and two-dimensional (2D) measurements defined by the World ă Health Organization (WHO) with tumor volume measurements as the standard ă of reference and to determine which method correlates best with clinical ă outcomes. ă Materials and Methods: This retrospective study was approved by the ă institutional review board of three institutions. Seventy-four patients ă (mean age +/- standard deviation, 14.5 years +/- 6.5) with newly ă diagnosed Ewing sarcoma treated at three medical centers were evaluated. ă Primary tumor size was assessed on pre-and posttreatment magnetic ă resonance images according to 1D RECIST, 2D WHO, and 3D COG ă measurements. Tumor responses were compared with the standard of ă reference (tumor volume) on the basis of RECIST, COG, and WHO ă therapeutic response thresholds. Agreement between the percentage ă reduction measurements of the methods was assessed with concordance ă correlation, Bland-Altman analysis, and Spearman rank correlation. ă Agreement between therapeutic responses was assessed with Kendall tau ă and unweighted kappa statistics. Tumor responses were compared with ă patient survival by using the log-rank test, Kaplan-Meier plots, and Cox ă regression. ă Results: Agreement with the reference standard was significantly better ă for 3D measurement than for 1D and 2D measurements on the basis of ă RECIST and COG therapeutic response thresholds (concordance correlation ă of 0.41, 0.72, and 0.84 for 1D, 2D, and 3D measurements, respectively; P ă

Keywords: quality (search for similar items in EconPapers)
Date: 2016-09
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Published in Radiology, 2016, 280 (3), pp.905-915. ⟨10.1148/radiol.2016151301⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482352

DOI: 10.1148/radiol.2016151301

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