Uterus transplantation in France: for which patients?

S. Huet, A. Tardieu (), M. Filloux, M. Essig, N. Pichon, J. F. Therme, P. Piver, Y. Aubard, J. M. Ayoubi, O. Garbin, P. Collinet (), A. Agostini, V. Lavoue, A. Piccardo and T. Gauthier
Additional contact information
S. Huet: UR LISC - Laboratoire d'ingénierie pour les systèmes complexes - IRSTEA - Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture
A. Tardieu: PBSF - Protéines : biochimie structurale et fonctionnelle - UPMC - Université Pierre et Marie Curie - Paris 6 - CNRS - Centre National de la Recherche Scientifique
N. Pichon: CHPOT - Coordination des Prélèvements d’Organes et de Tissus - CHU Limoges
P. Piver: Service de Gynécologie-Obstétrique [CHU Limoges] - CHU Limoges
Y. Aubard: Service de Gynécologie-Obstétrique [CHU Limoges] - CHU Limoges
P. Collinet: Hôpital Jeanne de Flandres - Université de Lille, Droit et Santé - CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
A. Agostini: Dipartimento di Matematica e Fisica - ROMA TRE - Università degli Studi Roma Tre = Roma Tre University
V. Lavoue: Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou], OSS - Oncogenesis Stress Signaling - UR - Université de Rennes - CRLCC - CRLCC Eugène Marquis - UNICANCER
T. Gauthier: Service de Gynécologie-Obstétrique [CHU Limoges] - CHU Limoges

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Abstract: Objective - Uterine infertility (UI), which can be caused by a variety of congenital or acquired factors, affects several thousand women in Europe. Uterus transplantation (UTx), at the current stage of research, offers hope for these women to be both the biological mother and the carrier of their child. However, the indications of UTx still need to be defined. The main aim of the study was to describe the different etiologies of UI and other data as marital and parental status from women requesting UTx who contacted us in the framework of a UTx clinical trial. Secondarily, we discussed the potential indications of UTx and their feasibility. Study design - This is an observational study. Results - Of a total of 139 patients with UI, 105 patients (75.5%) had uterine agenesis, making it the leading cause of UI in this sample. Among the patients with uterine agenesis, 25% had a solitary kidney and 44.7% had undergone vaginal reconstruction. Peripartum hysterectomy, hysterectomy for cancer, and hysterectomy for benign pathologies accounted for 9.4%, 7.2% and 5% of cases, respectively. Less common causes of UI included complete androgen insensitivity syndrome (2.2% of patients) and prenatal diethylstilbestrol exposure (0.7%). Approximately 14% of the women already had at least one child and 66% were in a couple living together for at least 2 years. Conclusion - UTx is still under evaluation and further research is under way. Nulliparous patients with no major medical or surgical history and with normal ovarian function, who meet the legal criteria for medically assisted reproduction, represent the best indications for UTx at this stage of its development.

Keywords: quality (search for similar items in EconPapers)
Date: 2016-10
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Published in European Journal of Obstetrics & Gynecology and Reproductive Biology, 2016, 205, pp.7-10. ⟨10.1016/j.ejogrb.2016.08.027⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482369

DOI: 10.1016/j.ejogrb.2016.08.027

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