Functional brain substrate of quality of life in patients with ă schizophrenia: A brain SPECT multidimensional analysis

Catherine Faget-Agius, Laurent Boyer (), Raphaëlle Richieri, Pascal Auquier (), Christophe Lançon () and Eric Guedj ()
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Laurent Boyer: C3M - Centre méditerranéen de médecine moléculaire - UNS - Université Nice Sophia Antipolis (1965 - 2019) - INSERM - Institut National de la Santé et de la Recherche Médicale - UniCA - Université Côte d'Azur
Raphaëlle Richieri: Laboratoire de santé publique évaluation des systèmes de soins et santé perçue, Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
Pascal Auquier: SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille
Christophe Lançon: Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
Eric Guedj: CERIMED - Centre Européen de Recherche en Imagerie médicale - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - ECM - École Centrale de Marseille - IPC - Institut Paoli-Calmettes - Fédération nationale des Centres de lutte contre le Cancer (FNCLCC) - CNRS - Centre National de la Recherche Scientifique, TIMONE - Hôpital de la Timone [CHU - APHM]

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Abstract: The aim of this study was to investigate the functional brain substrate ă of quality of life (QoL) in patients with schizophrenia. Participants ă comprised 130 right-handed patients with schizophrenia who underwent ă whole-brain single photon emission computed tomography (SPECT) with ă Tc-99m-labeled ethylcysteinate dimer (Tc-99m-ECD) for exploring ă correlations of regional cerebral blood flow (rCBF) with the eight ă dimensions score of the Schizophrenia Quality of Life questionnaire ă (S-QoL 18). A significant positive correlation was found between the ă global index of the S-QoL 18 and rCBF in the right superior temporal ă sulcus and between psychological well-being dimension and rCBF in ă Brodmann area (BA)6, BA8, BA9, and BA10 and between self-esteem ă dimension and rCBF in striatum and between family relationship dimension ă and rCBF in BA1, BA2, BA3, BA4, BA8, BA22, BA40, BA42 and BA44 and ă between relationship with friends dimension and rCBF in BA44 and between ă physical well-being dimension and rCBF in parahippocampal gyrus, and ă finally between autonomy dimension and rCBF in cuneus and precuneus. A ă significant negative correlation was found between resilience dimension ă and rCBF in precuneus and between sentimental life dimension and rCBF in ă BA10. Our findings provide neural correlates of QoL. Brain regions ă involved in cognitions, emotional information processing and social ă cognition underlie the different QoL dimensions. (C) 2016 Published by ă Elsevier Ireland Ltd.

Keywords: Quality (search for similar items in EconPapers)
Date: 2016-03
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Published in Psychiatry Research: Neuroimaging, 2016, 249, pp.67-75. ⟨10.1016/j.pscychresns.2016.02.005⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482504

DOI: 10.1016/j.pscychresns.2016.02.005

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