Prospective comparison of Ga-68-DOTATATE and F-18-FDOPA PET/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases

Aurelien Archier, Arthur Varoquaux, Philippe Garrigue, Marion Montava, Carole Guérin, Sophie Gabriel, Eva Beschmout, Isabelle Morange, Nicolas Fakhry, Frederic Castinetti (), Frédéric Sebag, Anne Barlier (), Anderson Loundou, Benjamin Guillet, Karel Pacak and David Taieh
Additional contact information
Arthur Varoquaux: CRMBM - Centre de résonance magnétique biologique et médicale - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - CNRS - Centre National de la Recherche Scientifique
Philippe Garrigue: VRCM - Vascular research center of Marseille - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale, CERIMED - Centre Européen de Recherche en Imagerie médicale - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - ECM - École Centrale de Marseille - IPC - Institut Paoli-Calmettes - Fédération nationale des Centres de lutte contre le Cancer (FNCLCC) - CNRS - Centre National de la Recherche Scientifique, Service de Radiopharmacie [Hôpital de la Timone- Hôpital Nord - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM] - Hôpital Nord [CHU - APHM]
Marion Montava: Service d'ORL, CHU Nord - LBA UMR T24 - Laboratoire de Biomécanique Appliquée - AMU - Aix Marseille Université - Université Gustave Eiffel
Carole Guérin: CHU Conception - Centre Hospitalier Universitaire Conception
Sophie Gabriel: IFA - Institute für arbeitsschutz deutschen gesetzlichen unfallversicherung
Isabelle Morange: AMU - Aix Marseille Université
Frederic Castinetti: CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique
Frédéric Sebag: Service de chirurgie générale et endocrinienne - TIMONE - Hôpital de la Timone [CHU - APHM]
Anne Barlier: CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique
Anderson Loundou: Unité d'Aide Méthodologique - APHM - Assistance Publique - Hôpitaux de Marseille - CHU Marseille
Benjamin Guillet: VRCM - Vascular research center of Marseille - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale, CERIMED - Centre Européen de Recherche en Imagerie médicale - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - ECM - École Centrale de Marseille - IPC - Institut Paoli-Calmettes - Fédération nationale des Centres de lutte contre le Cancer (FNCLCC) - CNRS - Centre National de la Recherche Scientifique, Service de Radiopharmacie [Hôpital de la Timone- Hôpital Nord - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM] - Hôpital Nord [CHU - APHM]

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Abstract: Purpose Pheochromocytomas/paragangliomas (PHEOs/PGLs) overexpress ă somatostatin receptors and recent studies have already shown excellent ă results in the localization of these tumors using Ga-68-labeled ă somatostatin analogs (Ga-68-DOTA-SSA), especially in patients with ă germline succinate dehydrogenase subunit B gene (SDHB) mutations and ă head and neck PGLs (HNPGLs). The value of Ga-68-DOTA-SSA has to be ă established in sporadic cases, including PHEOs. Thus, the aim of this ă study was to compare Ga-68-DOTATATE PET/CT, F-18-FDOPA PET/CT, and ă conventional imaging in patients with various PHEOs/PGLs with a special ă emphasis on sporadic cases, including those located in the adrenal ă gland. ă Design Ga-68-DOTATATE, F-18-FDOPA PET/CT, and conventional imaging ă (contrast-enhanced CT and MRI with MR angiography sequences) were ă prospectively performed in 30 patients (8 with SDHD mutations, 1 with a ă MAX mutation and 21 sporadic cases) with PHEO/PGL at initial diagnosis ă or relapse. ă Results The patient-based sensitivities were 93 % (28/30), 97 % ă (29/30), and 93 % (28/30) for Ga-68-DOTATATE PET/CT, F-18-FDOPA PET/CT, ă and conventional imaging, respectively. The lesion-based sensitivities ă were 93 % (43/46), 89 % (41/46), and 76 % (35/46) for Ga-68-DOTATATE ă PET/CT, F-18-FDOPA PET/CT, and conventional imaging respectively (p = ă 0.042). Ga-68-DOTATATE PET/CT detected a higher number of HNPGLs (30/30) ă than F-18-FDOPA PET/CT (26/30; p = 0.112) and conventional imaging ă (24/30; p = 0.024). Ga-68-DOTATATE PET/CT missed two PHEOs of a few ă millimeters in size and a large recurrent PHEO. One lesion was ă considered false-positive on Ga-68-DOTATATE PET/CT and corresponded to a ă typical focal lesion of fibrous dysplasia on MRI. Among the 11 lesions ă missed by conventional imaging, 7 were detected by conventional imaging ă with knowledge of the PET results (4 HNPGLs, 2 LNs, and 1 recurrent ă PHEO). ă Conclusion Ga-68-DOTATATE PET/CT is the most sensitive tool in the ă detection of HNPGLs, especially SDHD-related tumors, which may be very ă small and fail to concentrate sufficient F-18-FDOPA. The present study ă further expands the use of Ga-68-DOTATATE for all patients with HNPGLs, ă regardless of their genotype. Ga-68-DOTATATE PET/CT may be inferior to ă F-18-FDOPA PET/CT in the detection PHEOs.

Keywords: Quality (search for similar items in EconPapers)
Date: 2016-07
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Published in European Journal of Nuclear Medicine and Molecular Imaging, 2016, 43 (7), pp.1248-1257. ⟨10.1007/s00259-015-3268-2⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482530

DOI: 10.1007/s00259-015-3268-2

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