Working Memory Deficit as a Risk Factor for Severe Apathy in ă Schizophrenia: A 1-Year Longitudinal Study

Stephane Raffard (), Laure-Anne Gutierrez, Hanan Yazbek, Aurore Larue, Jean-Philippe Boulenger, Christophe Lançon (), Michel Benoit, Catherine Faget, Joanna Norton and Delphine Capdevielle ()
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Stephane Raffard: EPSYLON - Dynamique des capacités humaines et des conduites de santé - UM1 - Université Montpellier 1 - UPVM - Université Paul-Valéry - Montpellier 3 - UM - Université de Montpellier, CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
Laure-Anne Gutierrez: PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique - UM1 - Université Montpellier 1 - INSERM - Institut National de la Santé et de la Recherche Médicale - UM - Université de Montpellier, CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
Hanan Yazbek: EPSYLON - Dynamique des capacités humaines et des conduites de santé - UM1 - Université Montpellier 1 - UPVM - Université Paul-Valéry - Montpellier 3 - UM - Université de Montpellier, CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
Aurore Larue: CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
Jean-Philippe Boulenger: Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] - CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier] - Hôpital la Colombière [CHU Montpellier] - CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
Michel Benoit: IRPHE - Institut de Recherche sur les Phénomènes Hors Equilibre - AMU - Aix Marseille Université - ECM - École Centrale de Marseille - CNRS - Centre National de la Recherche Scientifique
Joanna Norton: PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique - UM1 - Université Montpellier 1 - INSERM - Institut National de la Santé et de la Recherche Médicale - UM - Université de Montpellier
Delphine Capdevielle: PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique - UM1 - Université Montpellier 1 - INSERM - Institut National de la Santé et de la Recherche Médicale - UM - Université de Montpellier, CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

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Abstract: Apathy, described as impaired motivation and goal-directed behavior, is ă a common yet often overlooked multidimensional psychopathological state ă in schizophrenia. Its underlying cognitive processes remain largely ă unexplored. Data was drawn from a longitudinal hospital study of ă patients with a DSM-IV diagnosis of schizophrenia; 137 (82.5%) ă participated at the 1-month follow-up and 81 (59.1%) at the 1-year ă follow-up. Apathy was assessed with the Lille Apathy Rating Scale, ă validated in French and in schizophrenia. Severe apathy, overall (total ă score > -13) and on 4 previously identified distinct dimensions, was ă considered. Episodic verbal learning was assessed with the California ă Verbal Learning Test, executive functioning with the Trail Making Test, ă the Six Element Test and the Stop Signal Paradigm and working memory ă with the Letter-Number Sequencing Test. After controlling for ă confounding variables, only episodic verbal learning was associated with ă severe overall apathy in the cross-sectional study. At 1 year, working ă memory was associated with an increased risk of severe overall apathy, ă adjusting for baseline apathy. Using a dimensional approach to apathy, ă specific types of cognition were found to be associated with specific ă dimensions of apathy. Our findings confirm the need for a ă multidimensional approach of negative symptoms in schizophrenia. ă Moreover, cognitive functioning could be a risk factor for developing ă severe apathy. Cognitive remediation may thus be a useful ă non-pharmacological intervention for treating apathy in schizophrenia ă patients.

Keywords: Quality; of; Life (search for similar items in EconPapers)
Date: 2016-05
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Published in Schizophrenia Bulletin, 2016, 42 (3), pp.642-651. ⟨10.1093/schbul/sbw002⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482616

DOI: 10.1093/schbul/sbw002

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