Risk of neuroblastoma, birth-related characteristics, congenital ă malformations and perinatal exposures: A pooled analysis of the ESCALE ă and ESTELLE French studies (SFCE)

Paula Rios, Helen D. Bailey, Laurent Orsi, Brigitte Lacour (), Dominique Valteau-Couanet, Dominique Levy, Nadège Corradini, Guy Leverger, Anne-Sophie Defachelles, Marion Gambart, Nicolas Sirvent, Estelle Thébaud, Stéphane Ducassou and Jacqueline Clavel
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Laurent Orsi: CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité - INRA - Institut National de la Recherche Agronomique - UPD7 - Université Paris Diderot - Paris 7 - UPD5 - Université Paris Descartes - Paris 5 - USPC - Université Sorbonne Paris Cité - INSERM - Institut National de la Santé et de la Recherche Médicale
Brigitte Lacour: RNTSE - Registre National des Tumeurs Solides de l'Enfant - CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy - Cancéropôle du Grand Est
Dominique Valteau-Couanet: Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy] - IGR - Institut Gustave Roussy
Dominique Levy: PSE - Paris School of Economics - UP1 - Université Paris 1 Panthéon-Sorbonne - ENS-PSL - École normale supérieure - Paris - PSL - Université Paris Sciences et Lettres - EHESS - École des hautes études en sciences sociales - ENPC - École nationale des ponts et chaussées - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, PSE - Paris-Jourdan Sciences Economiques - ENS-PSL - École normale supérieure - Paris - PSL - Université Paris Sciences et Lettres - INRA - Institut National de la Recherche Agronomique - EHESS - École des hautes études en sciences sociales - ENPC - École nationale des ponts et chaussées - CNRS - Centre National de la Recherche Scientifique
Nadège Corradini: Centre Léon Bérard [Lyon]
Guy Leverger: Hôpital Trousseau - CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
Nicolas Sirvent: Service de Pédiatrie, Unité d'Oncologie et Hématologie Pédiatrique - CHU Nice - Centre Hospitalier Universitaire de Nice
Estelle Thébaud: Service d'oncologie pédiatrique [Nantes] - CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Stéphane Ducassou: Hôpital Pellegrin - CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux - Groupe hospitalier Pellegrin
Jacqueline Clavel: CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité - INRA - Institut National de la Recherche Agronomique - UPD7 - Université Paris Diderot - Paris 7 - UPD5 - Université Paris Descartes - Paris 5 - USPC - Université Sorbonne Paris Cité - INSERM - Institut National de la Santé et de la Recherche Médicale

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Abstract: Neuroblastoma (NB), an embryonic tumour arising from neural crest cells, ă is the most common malignancy among infants. The aetiology of NB is ă largely unknown. We conducted a pooled analysis to explore whether there ă is an association between NB and preconception and perinatal factors ă using data from two French national population-based case-control ă studies. The mothers of 357 NB cases and 1783 controls younger than 6 ă years, frequency-matched by age and gender, responded to a telephone ă interview that focused on demographic, socioeconomic and perinatal ă characteristics, childhood environment, life-style and maternal ă reproductive history. Unconditional logistic regression was used to ă estimate pooled odds ratios and 95% confidence intervals. After ă controlling for matching variables, study of origin and potential ă confounders, being born either small (OR 1.4 95% CI 1.0-2.0) or large ă (OR 1.5 95% CI 1.1-2.2) for gestational age and, among children younger ă than 18 months, having congenital malformations (OR 3.6 95% CI ă 1.3-8.9), were significantly associated with NB. Inverse associations ă were observed with breastfeeding (OR 0.7 95% CI 0.5-1.0) and maternal ă use of any supplements containing folic acid, vitamins or minerals (OR ă 0.5 95% CI 0.3-0.9) during the preconception period. Our findings ă reinforce the hypothesis that fetal growth anomalies and congenital ă malformations may be associated with an increased risk of NB. Further ă investigations are needed in order to clarify the role of folic acid ă supplementation and breastfeeding, given their potential importance in ă NB prevention.

Keywords: Quality; of; Life (search for similar items in EconPapers)
Date: 2016-11
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Published in International Journal of Cancer, 2016, 139 (9), pp.1936-1948. ⟨10.1002/ijc.30239⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482620

DOI: 10.1002/ijc.30239

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