Different outcome of T cell acute lymphoblastic leukemia with ă translocation t(11;14) treated in two consecutive children leukemia ă group EORTC trials

Pauline Simon, Stefan Suciu, Emmanuelle Clappier, Hélène Cavé, Nicolas Sirvent, Genevieve Plat, Antoine Thyss, Françoise Méchinaud, Vitor M. Costa, Alina Ferster, Patrick Lutz, Françoise Mazingue, Dominique Plantaz, Emmanuel Plouvier, Yves Bertrand (), Yves Benoit, Nicole Dastugue, Pierre S. Rohrlich and Childrens Leukemia Grp Clg Europea
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Hélène Cavé: Département de génétique [Robert Debré] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - AP-HP Hôpital universitaire Robert-Debré [Paris] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
Nicolas Sirvent: Service de Pédiatrie, Unité d'Oncologie et Hématologie Pédiatrique - CHU Nice - Centre Hospitalier Universitaire de Nice
Genevieve Plat: CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
Antoine Thyss: Haematology - CHU Nice - Centre Hospitalier Universitaire de Nice
Françoise Méchinaud: Children's Cancer Center - The Royal Children's Hospital
Alina Ferster: HUDERF - Hôpital Universitaire des Enfants Reine Fabiola [Bruxelles, Belgique]
Patrick Lutz: Service de pédiatrie - CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
Françoise Mazingue: CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
Dominique Plantaz: Service Hématologie Infantile - CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
Emmanuel Plouvier: Service de pédiatrie - CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
Yves Bertrand: Hématologie et immunologie pédiatrique - HFME - Hôpital Femme Mère Enfant [CHU - HCL] - HCL - Hospices Civils de Lyon - HCL - Hospices Civils de Lyon - CHU Lyon - IHOPe - Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] - HCL - Hospices Civils de Lyon
Nicole Dastugue: Service Hématologie - IUCT-Oncopole [CHU Toulouse] - Pôle Biologie [CHU Toulouse] - CHU Toulouse - Centre Hospitalier Universitaire de Toulouse - Pôle IUCT [CHU Toulouse] - CHU Toulouse - Centre Hospitalier Universitaire de Toulouse

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Abstract: Acute lymphoblastic leukemia of T cell lineage (T-ALL) is an aggressive ă malignant disease which accounts for 15 % of childhood ALL. T(11;14) is ă the more frequent chromosomal abnormality in childhood T-ALL, but its ă prognostic value remained controversial. Our aim was to analyze the ă outcome of childhood T-ALL with t(11;14) to know if the presence of this ă translocation is associated with a poor prognosis. We conducted a ă retrospective study from a series of 20 patients with t(11;14), treated ă in two consecutive trials from the European Organization for Research ă and Treatment of Cancer Children Leukemia Group over a 19-year period ă from 1989 to 2008. There were no significant differences between the 2 ă consecutive groups of patients with t(11;14) regarding the clinical and ă biological features at diagnosis. Among 19 patients who reached complete ă remission, 9 patients relapsed. We noticed 7 deaths all relapse- or ă failure-related. In the 58881 study, a presence of t(11;14) was ă associated with a poor outcome with an event-free survival at 5 years at ă 22.2 % versus 65.1 % for the non-t(11;14) T-ALL (p = 0.0004). In the ă more recent protocol, the outcome of T-ALL with t(11;14) reached that of ă non-t(11;14) T-ALL with an event-free survival at 5 years at 65.5 versus ă 74.9 % (p = 0.93). The presence of t(11;14) appeared as a poor ă prognostic feature in the 58881 trial whereas this abnormality no longer ă affected the outcome in the 58951 study. This difference is probably ă explained by the more intensive chemotherapy in the latest trial.

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Date: 2016-01
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Published in Annals of Hematology, 2016, 95 (1), pp.93-103. ⟨10.1007/s00277-015-2515-8⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482631

DOI: 10.1007/s00277-015-2515-8

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