The Very Long-Term Outcome of Radiosurgery for Classical Trigeminal ă Neuralgia

Jean Régis, Constantin Tuleasca (), Noémie Resseguier (), Romain Carron, Anne Donnet, Shoji Yomo, Jean Gaudart () and Marc Levivier
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Jean Régis: Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition - Université de la Méditerranée - Aix-Marseille 2 - INSERM - Institut National de la Santé et de la Recherche Médicale, Service de neurochirurgie fontionnelle et stéréotaxique - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM]
Constantin Tuleasca: SP Lab - Laboratoire de Traitement du signal [EPFL] / Signal Processing Laboratories - EPFL - Ecole Polytechnique Fédérale de Lausanne, Service de neurochirurgie fontionnelle et stéréotaxique - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM], UNIL - Université de Lausanne = University of Lausanne
Noémie Resseguier: SESSTIM - U912 INSERM - Aix Marseille Univ - IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale
Romain Carron: Service de neurochirurgie fontionnelle et stéréotaxique - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM]
Anne Donnet: Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM]
Shoji Yomo: Service de neurochirurgie fontionnelle et stéréotaxique - APHM - Assistance Publique - Hôpitaux de Marseille - TIMONE - Hôpital de la Timone [CHU - APHM]
Jean Gaudart: SESSTIM - U912 INSERM - Aix Marseille Univ - IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale, AMU - Aix Marseille Université
Marc Levivier: UNIL - Université de Lausanne = University of Lausanne

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Abstract: Background: Radiosurgery is one of the neurosurgical alternatives for ă intractable trigeminal neuralgia (TN). Objective: Although acceptable ă short-/mid-term outcomes have been reported, long-term results have not ă been well documented. Methods: We report the long-term results in 130 ă patients who underwent radiosurgery for classical TN and were ă subsequently monitored through at least 7 years (median = 9.9, range = ă 7-14.5) of follow-up. Results: The median age was 66.5 years. A total of ă 122 patients (93.8%) became pain free (median delay = 15 days) after ă the radiosurgery procedure (Barrow Neurological Institute, BNI class I ă IIIa). The probability of remaining pain free without medication at 3, ă 5, 7 and 10 years was 77.9, 73.8, 68 and 51.5%, respectively. Fifty-six ă patients (45.9%) who were initially pain free experienced recurrent ă pain (median delay = 73.1 months). However, at 10 years, of the initial ă 130 patients, 67.7% were free of any recurrence requiring new surgery ă (BNI class I IIIa). The new hypesthesia rate was 20.8% (median delay of ă onset = 12 months), and only 1 patient (0.8%) reported very bothersome ă hypesthesia. Conclusions: The long-term results were comparable to those ă from our general series (recently published), and the high probability ă of long-lasting pain relief and rarity of consequential complications of ă radiosurgery may suggest it as a first and/or second-line treatment for ă classical, drug-resistant TN. (C) 2016 S. Karger AG, Basel

Keywords: Quality; of; Life (search for similar items in EconPapers)
Date: 2016
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Published in Stereotactic and Functional Neurosurgery, 2016, 94 (1), pp.24-32

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482648

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