Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Magnus Johannesson, David Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp Koellinger, Daniel Benjamin, Meike Bartels, David Cesarini, Aysu Okbay, Bart M. L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark Alan Fontana, S. Fleur W. Meddens, Richard Karlsson Linnér, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V. Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Gudmar Thorleifsson, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M. Willems, Wei Zhao, Lifelines Cohort Study, Najaf Amin, Andrew Bakshi, Sven Bergmann, Gyda Bjornsdottir, Patricia A. Boyle, Samantha Cherney, Simon R. Cox, Gail Davies, Oliver S. P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J. Forstner, Christian Gieger, Richa Gupta, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. de Jager (), Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, Lude Franke, Ruifang Li-Gao, David C. Liewald, Marisa Koini, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Miriam A. Mosing, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-R\r Aback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret I. Boomsma, Harold Snieder, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. Duijn, Johan G. Eriksson, Ute Bültmann, Eco J. C. Geus, Patrick Groenen (), Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M. A. Haworth, Caroline Hayward, Andrew C. Heath, David A. Hinds, Elina Hyppönen, William G. Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L. R. Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura D. Kubzansky, Terho Lehtimäki, Patrik K. E. Magnusson, Nicholas G. Martin, Matt Mcgue, Andres Metspalu, Melinda Mills, Renée Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R. Rosendaal, Hester M. Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Behrooz Z. Alizadeh, Thorkild I. A. Sørensen, Tim D. Spector, John M. Starr, Kari Stefansson, Andrew Steptoe, Antonio Terracciano, Unnur Thorsteinsdottir, Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Jian Yang, Dalton C. Conley, George Davey Smith and Albert Hofman
Additional contact information
Sarah E. Medland: Queensland Institute of Medical Research
Jacob Gratten: UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
Juan R. Gonzalez: CREAL - Center for Research in Environmental Epidemiology - UPF - Universitat Pompeu Fabra [Barcelona] - Catalunya ministerio de salud, UPF - Universitat Pompeu Fabra [Barcelona], CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
Tian Liu: ISM - Institut des Sciences Moléculaires - UB - Université de Bordeaux - École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB) - INC-CNRS - Institut de Chimie - CNRS Chimie - CNRS - Centre National de la Recherche Scientifique
Olli Raitakari: Tampere University Hospital, University of Turku
Rajesh Rawal: King‘s College London
Juho Wedenoja: Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Wei Zhao: AP-HP Hôpital universitaire Robert-Debré [Paris] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
Sven Bergmann: UNIL - Université de Lausanne = University of Lausanne
Simon R. Cox: BCU - Birmingham City University
Christian Gieger: HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
Jouke-Jan Hottenga: King‘s College London
Meena Kumari: Department of Epidemiology and Public Health - UCL - University College of London [London]
Lenore J. Launer: Donders Institute for Brain, Cognition and Behaviour - Radboud University [Nijmegen]
David C. Liewald: The University of Edinburgh
Grant W. Montgomery: Queensland Institute of Medical Research
Angelina R. Sutin: FSU - Florida State University [Tallahassee]
Lei Yu: Wuhan University [China]
David A. Bennett: Rush University Medical Center [Chicago]
Cornelia M. Duijn: Department of Epidemiology [Rotterdam] - Erasmus MC - Erasmus University Medical Center [Rotterdam]
Jaakko Kaprio: National Institute for Health and Welfare [Helsinki]
Nancy L. Pedersen: MEB - Department of Medical Epidemiology and Biostatistics - Karolinska Institutet [Stockholm]
Helena Schmidt: Dpt of Pharmacology and Personalised Medicine [Maastricht] - Maastricht University [Maastricht]
Andrew Steptoe: Department of Epidemiology and Public Health - UCL - University College of London [London]
Antonio Terracciano: FSU - Florida State University [Tallahassee]
André G. Uitterlinden: Erasmus MC - Erasmus University Medical Center [Rotterdam]

Post-Print from HAL

Abstract: Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (\textbarρ^\textbar ? 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Keywords: Behavioural genetics; Genome-wide association studies (search for similar items in EconPapers)
Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (33)

Published in Nature Genetics, 2016, 48 (6), pp.624-633. ⟨10.1038/ng.3552⟩

There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-02017373

DOI: 10.1038/ng.3552

Access Statistics for this paper

More papers in Post-Print from HAL
Bibliographic data for series maintained by CCSD ().