Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration

Erno Hermans, Hein van Marle, Lindsey Ossewaarde, Marloes Henckens, Shaozheng Qin, Marlieke van Kesteren, Vincent Schoots, Helena Cousijn, Mark Rijpkema, Robert Oostenveld and Guillén Fernández
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Marloes Henckens: Radboud University [Nijmegen], McGill University = Université McGill [Montréal, Canada]
Shaozheng Qin: Stanford School of Medicine [Stanford] - Stanford Medicine - Stanford University
Mark Rijpkema: Donders Center for Cognitive Neuroimaging - Donders Centre for Cognitive Neuroimaging - Radboud University [Nijmegen]
Robert Oostenveld: Donders Institute for Brain, Cognition and Behaviour - Radboud University [Nijmegen]
Guillén Fernández: Department of Psychiatry - Department of Psychiatry

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Abstract: Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the brain. We investigated this brain-state shift in humans. During exposure to a fear-related acute stressor, responsiveness and interconnectivity within a network including cortical (frontoinsular, dorsal anterior cingulate, inferotemporal, and temporoparietal) and subcortical (amygdala, thalamus, hypothalamus, and midbrain) regions increased as a function of stress response magnitudes. β-adrenergic receptor blockade, but not cortisol synthesis inhibition, diminished this increase. Thus, our findings reveal that noradrenergic activation during acute stress results in prolonged coupling within a distributed network that integrates information exchange between regions involved in autonomic-neuroendocrine control and vigilant attentional reorienting.

Keywords: cognitive neuroscience; stress (search for similar items in EconPapers)
Date: 2011-11-25
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Citations: View citations in EconPapers (3)

Published in Science, 2011, 334 (6059), pp.1151-1153. ⟨10.1126/science.1209603⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-03188207

DOI: 10.1126/science.1209603

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