Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population

Benjamin C. Trumble, Jacob Negrey, Stephanie Koebele, Randall C. Thompson, L. Samuel Wann, Adel H. Allam, Bret A. Beheim, Linda Sutherland, James Sutherland, Daniel Eid Rodriguez, David E. Michalik, Christophe J. Rowan, Guido Lombardi, Angela Garcia, Daniel Cummings, Edmond Seabright, Sarah Alami, Thomas S. Kraft, Paul L. Hooper, Kenneth Buetow, Andrei Irimia, Margaret Gatz, Jonathan Stieglitz, Michael Gurven, Hillard Kaplan and Gregory Thomas
Additional contact information
Benjamin C. Trumble: Unknown
Jacob Negrey: Unknown
Stephanie Koebele: Unknown
Randall C. Thompson: Unknown
L. Samuel Wann: Unknown
Adel H. Allam: Unknown
Bret A. Beheim: Unknown
Linda Sutherland: Unknown
James Sutherland: Unknown
Daniel Eid Rodriguez: Unknown
David E. Michalik: Unknown
Christophe J. Rowan: Unknown
Guido Lombardi: Unknown
Angela Garcia: Unknown
Daniel Cummings: Unknown
Edmond Seabright: Unknown
Sarah Alami: Unknown
Thomas S. Kraft: Unknown
Paul L. Hooper: Unknown
Kenneth Buetow: Unknown
Andrei Irimia: Unknown
Margaret Gatz: Unknown
Jonathan Stieglitz: IAST - Institute for Advanced Study in Toulouse
Michael Gurven: Unknown
Hillard Kaplan: Unknown
Gregory Thomas: Unknown

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Abstract: In industrialized populations low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk, and low coronary artery calcium scores. In this cross-sectional community-based study, 719 Tsimane forager-horticulturalists in the Bolivian Amazon aged 40+ years underwent computed tomography (49.8% male, mean age 57.6 years). Coronary artery calcium levels were low; 84.5% had no coronary artery calcium. Zero inflated negative binomial models found testosterone was positively associated with coronary artery calcium for the full sample (IRR= 1.477, 95% CI 1.001-2.170, p=0.031), and in a male-only subset (IRR=1.532, 95% CI 0.993-2.360, p=0.053). Testosterone was also positively associated with clinically relevant coronary atherosclerosis (calcium >100 Agatston units) in the full sample (OR = 1.984, 95% CI 1.202-3.275, p=0.007) and when limited to male only sample (OR= 2.032, 95% CI 1.118-4.816, p=0.024). Individuals with coronary artery calcium >100 had 20% higher levels of testosterone than those with calcium

Keywords: Testosterone; Cardiovascular disease; Evolutionary mismatch; Coronary artery calcium (search for similar items in EconPapers)
Date: 2023-11
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Published in Evolution, Medicine, and Public Health, 2023, vol. 11 (n° 1), pp.472-484. ⟨10.1093/emph/eoad039⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-04547874

DOI: 10.1093/emph/eoad039

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