Segmentation and morphometry of intracranial internal carotid artery calcification in relation to brain atrophy

Xiao Xu, Nikhil Chaudhari, Phoebe E. Imms, Nahian Chowdhury, Fangyun C. Liu, Jorge A. Solis Galvan, Bavrina Bigjahan, Grant Schleifer, Maria Ashna, Blake Hannagan, Giuseppe Barisano, Daniel Cummings, Daniel Eid Rodriguez, Paul L. Hooper, Edmond Seabright, Randall C. Thompson, Benjamin C. Trumble, Michael Gurven, Jonathan Stieglitz, Caleb Ellicott Finch, Linda Sutherland, James Sutherland, Helena Chui, Margaret Gatz, Wendy Mack, Hillard Kaplan and Andrei Irimia
Additional contact information
Xiao Xu: USC - University of Southern California
Nikhil Chaudhari: USC - University of Southern California
Phoebe E. Imms: USC - University of Southern California
Nahian Chowdhury: USC - University of Southern California
Fangyun C. Liu: USC - University of Southern California
Jorge A. Solis Galvan: USC - University of Southern California
Bavrina Bigjahan: USC - University of Southern California
Grant Schleifer: HMS - Harvard Medical School [Boston]
Maria Ashna: USC - University of Southern California
Blake Hannagan: Chapman University
Giuseppe Barisano: Stanford University
Daniel Cummings: Chapman University
Daniel Eid Rodriguez: UMSS - Universidad Mayor de San Simón [Cochabamba, Bolivie]
Paul L. Hooper: Chapman University
Edmond Seabright: UM6P - Université Mohammed VI Polytechnique = Mohammed VI Polytechnic University [Ben Guerir]
Randall C. Thompson: UMKC - University of Missouri [Kansas City] - University of Missouri System
Benjamin C. Trumble: ASU - Arizona State University [Tempe]
Michael Gurven: UC - University of California
Jonathan Stieglitz: IAST - Institute for Advanced Study in Toulouse, TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - Comue de Toulouse - Communauté d'universités et établissements de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
Caleb Ellicott Finch: USC - University of Southern California
Linda Sutherland: MemorialCare Health Systems, Fountain Valley, California
James Sutherland: MemorialCare Health Systems, Fountain Valley, California
Helena Chui: USC - University of Southern California
Margaret Gatz: USC - University of Southern California
Wendy Mack: USC - University of Southern California
Hillard Kaplan: IAST - Institute for Advanced Study in Toulouse, TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - Comue de Toulouse - Communauté d'universités et établissements de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
Andrei Irimia: USC - University of Southern California

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Abstract: Purpose Intracranial internal carotid artery calcification (iICAC) is a form of intracranial arteriosclerosis and is associated with an elevated risk of stroke and dementia. However, iICAC's relationship with brain atrophy remains poorly understood. We aimed to automatically quantify iICAC morphometric characteristics and evaluate their associations with regional brain volumes (BVs). Methods We developed an automated approach to compute iICAC surface area and thickness from CT brain scans in a sample of physically active South American subsistence farmers (n = 1,232, age range: 40 years to 92 years, 48.1% female, 794 Tsimane and 438 Moseten). Linear regression models were used to assess associations between two iICAC features and regional BVs, adjusted for age, sex, population, and total intracranial volume. Results Significant negative relationships were found between regional BVs and iICAC surface area, but not iICAC thick- ness. Frontal, parietal, temporal, and subcortical BVs exhibited significant negative associations with iICAC surface area (standardized β range: -0.146 to -0.066, p ≤ 0.013), while the occipital BV did not (standardized βlef t = -0.035, p = 0.249; βright = 0.007, p = 0.810). Subcortical BVs demonstrated the strongest negative associations with iICAC surface area (standardized βlef t = -0.146, p

Keywords: Brain volume; Computed tomography; Intracranial artery calcification; Morphometry (search for similar items in EconPapers)
Date: 2026-03
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Published in Neuroradiology, 2026, ⟨10.1007/s00234-026-03918-9⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-05555840

DOI: 10.1007/s00234-026-03918-9

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