Nonlinearities in Drug Release Process from Polymeric Microparticles: Long-Time-Scale Behaviour

Elena Simona Bacaita, Costica Bejinariu, Borsos Zoltan, Catalina Peptu, Gabriela Andrei, Marcel Popa, Daniela Magop and Maricel Agop

Journal of Applied Mathematics, 2012, vol. 2012, 1-26

Abstract:

A theoretical model of the drug release process from polymeric microparticles (a particular type of polymer matrix), through dispersive fractal approximation of motion, is built. As a result, the drug release process takes place through cnoidal oscillations modes of a normalized concentration field. This indicates that, in the case of long-time-scale evolutions, the drug particles assemble in a lattice of nonlinear oscillators occur macroscopically, through variations of drug concentration. The model is validated by experimental results.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:hin:jnljam:653720

DOI: 10.1155/2012/653720

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