Assessing Health-Related Quality-of-Life in Prenatal Diagnosis Comparing Chorionic Villi Sampling and Amniocentesis: A Technical Report

David Feeny, Marie Townsend, William Furlong, Darrell Tomkins, Gail Robinson, George Torrance, Patrick Mohide and Qinan Wang
Additional contact information
Marie Townsend: Faculty of Health Sciences, McMaster University
William Furlong: Centre for Health Economics and Policy Analysis, Department of Clinical Epidemiology and Biostatistics, McMaster University, Health Utilities Inc, Dundas
Darrell Tomkins: Department of Medical Genetics, University of Alberta
Gail Robinson: Departments of Psychiatry and Obstetrics and Gynaecology, University of Toronto
George Torrance: Centre for Health Economics and Policy Analysis, Department of Clinical Epidemiology and Biostatistics, McMaster University, Innovus Research Inc, Burlington
Patrick Mohide: Department of Obstetrics and Gynaecology, McMaster University
Qinan Wang: Nanyang Technological University, Singapore

No 2000-04, Centre for Health Economics and Policy Analysis Working Paper Series from Centre for Health Economics and Policy Analysis (CHEPA), McMaster University, Hamilton, Canada

Abstract: Objectives. To assess the health-related quality-of-life (HRQL) effects of chorionic villi sampling (CVS) and genetic amniocentesis (GA) prenatal diagnosis, including factors related to both the processes and the outcomes. Study Design. The HRQL of one hundred twenty six women participating in a randomized controlled clinical trial of CVS versus GA in Toronto and Hamilton, Ontario was assessed in four interviews at weeks 8, 13, 18, and 22 of pregnancy. Statistical analyses included analysis of variance, repeated measures analysis of covariance, chi-square, Fisher’s exact test, Student’s t-tests, and paired t-tests. Results. Utility scores for patients undergoing CVS exceeded those for GA patients at week 18 (p = 0.04). Utility scores for hypothetical health states did not differ significantly by trial arm. Conclusions. CVS results in slightly improved HRQL relative to GA during the second trimester of pregnancy. This advantage needs to be weighed against the high disutility patients attach to infrequent outcomes associated with pregnancy losses, equivocal diagnoses, and diagnostic inaccuracy.

Keywords: Prenatal diagnosis; health-related quality of life; genetic amniocentesis; chorionic villi sampling; utility scores (search for similar items in EconPapers)
Pages: 47 pages
Date: 2000
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Citations: View citations in EconPapers (1)

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