Role of Hepatitis B Virus Large Surface Protein in Promoting Activation of Nuclear SREBPs via ER Stress: Implications for Hepatocellular Carcinoma

Subir Ghosh

International Journal of Biology, 2021, vol. 11, issue 2, 13

Abstract: One of the most common fatal malignancies in the world is Hepatocellular carcinoma (HCC) and hepatitis B virus (HBV) infection has been identified as a leading risk factor for HCC. Studies have suggested that during infection the large surface viral protein of HBV (LS protein) is targeted to the endoplasmic reticulum (ER) of the host liver cell, where its accumulation causes ER stress leading to HCC. The LS protein is also believed to stimulate the lipogenic activity of the ATP citrate lyase (ACL) enzyme, leading to excessive synthesis of lipids required for the rapidly dividing liver tumor cell. Here, I propose a hypothesis linking viral LS protein-induced ER stress to generation of the mature transcriptionally active nuclear form of sterol regulatory element-binding protein (nSREBP). nSREBP translocates to the nucleus and binds to sterol regulatory elements (SRE) present in the ATP citrate lyase (ACL) gene promoter, thereby elevating ACL transcription levels and overproduction of the ACL enzyme protein. Inhibition of LS protein activity in the ER may provide a therapeutic strategy in treating HBV induced HCC.

Date: 2021
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://ccsenet.org/journal/index.php/ijb/article/download/0/0/38472/39058 (application/pdf)
https://ccsenet.org/journal/index.php/ijb/article/view/0/38472 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:ibn:ijbjnl:v:11:y:2021:i:2:p:13

Access Statistics for this article

More articles in International Journal of Biology from Canadian Center of Science and Education Contact information at EDIRC.
Bibliographic data for series maintained by Canadian Center of Science and Education ().