Synthesis of 6H-thiochromeno [3, 4-b] Quinoxaline Derivatives and their Antifungal Activities

Peng Wei, Jingjing Liu, Junjie Ma and Gengliang Yang

Modern Applied Science, 2010, vol. 4, issue 12, 136

Abstract: Objective- To design to synthesize 6H-thiochromeno [3, 4-b] quinoxaline derivatives and evaluate their antifungal activities. Methods- The target compounds were prepared from substituted thiophenol by several steps, and separated by column chromatography. Results- Four new unreported compounds were obtained. All compounds were confirmed by 1 H NMR and MS spectral analysis. Preliminary pharmacological test showed that two compounds both possessed potential antifungal activities.Conclusion- The synthesized 6H-thiochromeno [3, 4-b] quinoxaline derivatives had certain antifungal activities in some tested fungal strains in vitro.

Date: 2010
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