Nonalcoholic Steatohepatitis Animal Model, Induced by High-Fat Diet and Tetracycline

David Areshidze, Lyudmila Timchenko, Ivan Syomin, Maria Kozlova and Igor. Rzhepakovsky

Modern Applied Science, 2015, vol. 9, issue 1, 170

Abstract: As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis which is characterized by obesity, violation of the structural organization, a fabric necrosis, formation of fibrosis of a liver. The developed model of non-alcoholic steatohepatitis allows to study also staging of development of a fatty desease of the liver which is characterized by formation of a steatogepatitis and fibrosis. In quality the inducing factors the high-fat diet and antibiotics were used. The offered NASH model can be used in the field of chronic experiments for an assessment of extent of violation of a functional condition of hepatobiliary system and for search of the effective pharmacotheurapeutichepatoprotective agents.

Date: 2015
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