Enhancement of Ethanol Production Using a Hybrid of Firefly Algorithm and Dynamic Flux Balance Analysis

Wan Ting Leong, Mohd Saberi Mohamad, Kohbalan Moorthy, Yee Wen Choon, Hasyiya Karimah Adli, Khairul Nizar Syazwan W. S. W., Loo Keat Wei and Nazar Zaki
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Wan Ting Leong: Universiti Teknologi Malaysia, Malaysia
Mohd Saberi Mohamad: United Arab Emirates University, UAE
Kohbalan Moorthy: Universiti Malaysia Pahang, Malaysia
Yee Wen Choon: Universiti Malaysia Kelantan, Malaysia
Hasyiya Karimah Adli: Universiti Malaysia Kelantan, Malaysia
Khairul Nizar Syazwan W. S. W.: Universiti Malaysia Kelantan, Malaysia
Loo Keat Wei: Universiti Tunku Abdul Rahman, Malaysia
Nazar Zaki: United Arab Emirate University, UAE

International Journal of Swarm Intelligence Research (IJSIR), 2022, vol. 13, issue 1, 1-13

Abstract: Many high-demand industrial products are generated by microorganisms, including fuels, food, vitamins, and other chemicals. Metabolic engineering is the method of circumventing cellular control to manufacture a desirable product or to create a new product that the host cells do not normally need to produce. One of the objectives of microorganism metabolic engineering is to maximise the production of a desired product. However, owing to the structure of the regulatory cellular and metabolic network, identifying specific genes to be knocked out is difficult. The development of optimization algorithms often confronts issues such as easily trapping in local maxima and handling multivariate and multimodal functions inefficiently. To predict the gene knockout list that can generate high yields of desired product, a hybrid of Firefly Algorithm and Dynamic Flux Balance Analysis (FADFBA) is proposed. This paper focuses on the ethanol production of Escherichia coli (E. coli). The findings of the experiments include gene lists, ethanol production, growth rate, and the performance of FADFBA.

Date: 2022
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