Advanced Glycation End Products Levels and Carotid Intima Media Thickness in Patients With Rheumatoid Arthritis

Ines Knani, Hassan Bouzidi, Albert Lecube, Jawhar Gharbi and Mohsen Kerkeni

Journal of Biology and Life Science, 2019, vol. 10, issue 2, 58-70

Abstract: Introduction, No data regarding the relationship of carotid intima media thickness (IMT) and serum advanced glycation end products (AGEs) levels in patients with rheumatoid arthritis (RA). The aim of this study is to evaluate the association between IMT and serum pentosidine, CML and MGO levels in patients with longstanding RA. Methods, In a cross-sectional study, 80 consecutive RA patients with longstanding disease were included and compared with 30 age and sex-matched healthy controls. IMT was measured using ultrasonography. AGEs such as pentosidine, N x-carboxymethyllysine (CML) and methylglyoxal (MGO) as an intermediate of glycation, were determined by ELISA. Results, Serum pentosidine, CML and MGO levels were increased in RA patients vs control subjects (P = 0.001; P

Keywords: pentosidine; N x-carboxymethyllysine; methylglyoxal; carotid intima media thickness; rheumatoid arthritis (search for similar items in EconPapers)
Date: 2019
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