Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Mark R. Viant (), Timothy M. D. Ebbels, Richard D. Beger, Drew R. Ekman, David J. T. Epps, Hennicke Kamp, Pim E. G. Leonards, George D. Loizou, James I. MacRae, Bennard Ravenzwaay, Philippe Rocca-Serra, Reza M. Salek, Tilmann Walk and Ralf J. M. Weber
Additional contact information
Mark R. Viant: University of Birmingham
Timothy M. D. Ebbels: Imperial College London
Richard D. Beger: NCTR
Drew R. Ekman: US EPA
David J. T. Epps: University of Birmingham
Hennicke Kamp: BASF SE
Pim E. G. Leonards: Vrije Universiteit Amsterdam
George D. Loizou: Health and Safety Executive
James I. MacRae: The Francis Crick Institute
Bennard Ravenzwaay: BASF SE
Philippe Rocca-Serra: University of Oxford
Reza M. Salek: International Agency for Research on Cancer
Tilmann Walk: BASF Metabolome Solutions
Ralf J. M. Weber: University of Birmingham

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases.

Date: 2019
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DOI: 10.1038/s41467-019-10900-y

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