The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria

Chang Liu, Nan Zhou, Meng-Xuan Du, Yu-Tong Sun, Kai Wang, Yu-Jing Wang, Dan-Hua Li, Hai-Ying Yu, Yuqin Song, Bing-Bing Bai, Yuhua Xin, Linhuan Wu, Cheng-Ying Jiang, Jie Feng, Hua Xiang, Yuguang Zhou, Juncai Ma, Jun Wang, Hong-Wei Liu () and Shuang-Jiang Liu ()
Additional contact information
Chang Liu: Institute of Microbiology, Chinese Academy of Sciences
Nan Zhou: Institute of Microbiology, Chinese Academy of Sciences
Meng-Xuan Du: Institute of Microbiology, Chinese Academy of Sciences
Yu-Tong Sun: Institute of Microbiology, Chinese Academy of Sciences
Kai Wang: University of Chinese Academy of Sciences
Yu-Jing Wang: Institute of Microbiology, Chinese Academy of Sciences
Dan-Hua Li: Institute of Microbiology, Chinese Academy of Sciences
Hai-Ying Yu: Institute of Microbiology, Chinese Academy of Sciences
Yuqin Song: Institute of Microbiology, Chinese Academy of Sciences
Bing-Bing Bai: Chinese Academy of Sciences
Yuhua Xin: Chinese Academy of Sciences
Linhuan Wu: Chinese Academy of Sciences
Cheng-Ying Jiang: Institute of Microbiology, Chinese Academy of Sciences
Jie Feng: Institute of Microbiology, Chinese Academy of Sciences
Hua Xiang: Institute of Microbiology, Chinese Academy of Sciences
Yuguang Zhou: Chinese Academy of Sciences
Juncai Ma: Chinese Academy of Sciences
Jun Wang: University of Chinese Academy of Sciences
Hong-Wei Liu: University of Chinese Academy of Sciences
Shuang-Jiang Liu: Institute of Microbiology, Chinese Academy of Sciences

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Mice are widely used as experimental models for gut microbiome (GM) studies, yet the majority of mouse GM members remain uncharacterized. Here, we report the construction of a mouse gut microbial biobank (mGMB) that contains 126 species, represented by 244 strains that have been deposited in the China General Microorganism Culture Collection. We sequence and phenotypically characterize 77 potential new species and propose their nomenclatures. The mGMB includes 22 and 17 species that are significantly enriched in ob/ob and wild-type C57BL/6J mouse cecal samples, respectively. The genomes of the 126 species in the mGMB cover 52% of the metagenomic nonredundant gene catalog (sequence identity ≥ 60%) and represent 93–95% of the KEGG-Orthology-annotated functions of the sampled mouse GMs. The microbial and genome data assembled in the mGMB enlarges the taxonomic characterization of mouse GMs and represents a useful resource for studies of host-microbe interactions and of GM functions associated with host health and diseases.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-13836-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13836-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-13836-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().