Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Peter J. Vuillermin (), Martin O’Hely, Fiona Collier, Katrina J. Allen, Mimi L. K. Tang, Leonard C. Harrison, John B. Carlin, Richard Saffery, Sarath Ranganathan, Peter D. Sly, Lawrence Gray, John Molloy, Angela Pezic, Michael Conlon, David Topping, Karen Nelson, Charles R. Mackay, Laurence Macia, Jennifer Koplin, Samantha L. Dawson, Margarita Moreno-Betancur and Anne-Louise Ponsonby
Additional contact information
Peter J. Vuillermin: Deakin University, School of Medicine
Martin O’Hely: Deakin University, School of Medicine
Fiona Collier: Deakin University, School of Medicine
Katrina J. Allen: The Murdoch Children’s Research Institute
Mimi L. K. Tang: The Murdoch Children’s Research Institute
Leonard C. Harrison: The University of Melbourne
John B. Carlin: The Murdoch Children’s Research Institute
Richard Saffery: The Murdoch Children’s Research Institute
Sarath Ranganathan: The Murdoch Children’s Research Institute
Peter D. Sly: The Murdoch Children’s Research Institute
Lawrence Gray: Deakin University, School of Medicine
John Molloy: Deakin University, School of Medicine
Angela Pezic: The Murdoch Children’s Research Institute
Michael Conlon: Commonwealth Science and Industrial Research Organisation
David Topping: Commonwealth Science and Industrial Research Organisation
Karen Nelson: J. Craig Venter Institute
Charles R. Mackay: Monash University
Laurence Macia: University of Sydney, Charles Perkins Centre
Jennifer Koplin: The Murdoch Children’s Research Institute
Samantha L. Dawson: Deakin University, School of Medicine
Margarita Moreno-Betancur: The Murdoch Children’s Research Institute
Anne-Louise Ponsonby: The Murdoch Children’s Research Institute

Nature Communications, 2020, vol. 11, issue 1, 1-7

Abstract: Abstract In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri.

Date: 2020
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DOI: 10.1038/s41467-020-14552-1

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