Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter

Andreas Kaczmarczyk, Antje M. Hempel, Christoph Arx, Raphael Böhm, Badri N. Dubey, Jutta Nesper, Tilman Schirmer, Sebastian Hiller and Urs Jenal ()
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Andreas Kaczmarczyk: University of Basel
Antje M. Hempel: University of Basel
Christoph Arx: University of Basel
Raphael Böhm: University of Basel
Badri N. Dubey: University of Basel
Jutta Nesper: University of Basel
Tilman Schirmer: University of Basel
Sebastian Hiller: University of Basel
Urs Jenal: University of Basel

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here we demonstrate that a gradual increase in the concentration of the second messenger c-di-GMP determines precise gene expression during G1/S transition in Caulobacter crescentus. We show that c-di-GMP stimulates the kinase ShkA by binding to its central pseudo-receiver domain, activates the TacA transcription factor, and initiates a G1/S-specific transcription program leading to cell morphogenesis and S-phase entry. Activation of the ShkA-dependent genetic program causes c-di-GMP to reach peak levels, which triggers S-phase entry and promotes proteolysis of ShkA and TacA. Thus, a gradual increase of c-di-GMP results in precise control of ShkA-TacA activity, enabling G1/S-specific gene expression that coordinates cell cycle and morphogenesis.

Date: 2020
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DOI: 10.1038/s41467-020-14585-6

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