Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury

Sofia Meyer zu Reckendorf (), Christine Brand, Maria T. Pedro, Jutta Hegler, Corinna S. Schilling, Raissa Lerner, Laura Bindila, Gregor Antoniadis and Bernd Knöll ()
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Sofia Meyer zu Reckendorf: Ulm University
Christine Brand: Hospital Bogenhausen
Maria T. Pedro: Ulm University, District Hospital
Jutta Hegler: Ulm University
Corinna S. Schilling: Ulm University
Raissa Lerner: University Medical Centre of the Johannes Gutenberg University Mainz
Laura Bindila: University Medical Centre of the Johannes Gutenberg University Mainz
Gregor Antoniadis: Ulm University, District Hospital
Bernd Knöll: Ulm University

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Mammals differ in their regeneration potential after traumatic injury, which might be caused by species-specific regeneration programs. Here, we compared murine and human Schwann cell (SC) response to injury and developed an ex vivo injury model employing surgery-derived human sural nerves. Transcriptomic and lipid metabolism analysis of murine SCs following injury of sural nerves revealed down-regulation of lipogenic genes and regulator of lipid metabolism, including Pparg (peroxisome proliferator-activated receptor gamma) and S1P (sphingosine-1-phosphate). Human SCs failed to induce similar adaptations following ex vivo nerve injury. Pharmacological PPARg and S1P stimulation in mice resulted in up-regulation of lipid gene expression, suggesting a role in SCs switching towards a myelinating state. Altogether, our results suggest that murine SC switching towards a repair state is accompanied by transcriptome and lipidome adaptations, which are reduced in humans.

Date: 2020
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DOI: 10.1038/s41467-020-15915-4

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