Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila

Amandine Rambur, Corinne Lours-Calet, Claude Beaudoin, Julio Buñay, Marine Vialat, Vincent Mirouse, Amalia Trousson, Yoan Renaud, Jean-Marc A. Lobaccaro, Silvère Baron, Laurent Morel and Cyrille Joussineau ()
Additional contact information
Amandine Rambur: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Corinne Lours-Calet: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Claude Beaudoin: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Julio Buñay: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Marine Vialat: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Vincent Mirouse: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Amalia Trousson: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Yoan Renaud: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Jean-Marc A. Lobaccaro: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Silvère Baron: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Laurent Morel: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38
Cyrille Joussineau: Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, 28 place Henri Dunant, BP38

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract One of the most important but less understood step of epithelial tumourigenesis occurs when cells acquire the ability to leave their epithelial compartment. This phenomenon, described as basal epithelial cell extrusion (basal extrusion), represents the first step of tumour invasion. However, due to lack of adequate in vivo model, implication of emblematic signalling pathways such as Ras/Mitogen-Activated Protein Kinase (MAPK) and phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathways, is scarcely described in this phenomenon. We have developed a unique model of basal extrusion in the Drosophila accessory gland. There, we demonstrate that both Ras/MAPK and PI3K/AKT/mTOR pathways are necessary for basal extrusion. Furthermore, as in prostate cancer, we show that these pathways are co-activated. This occurs through set up of Epidermal Growth Factor Receptor (EGFR) and Insulin Receptor (InR) dependent autocrine loops, a phenomenon that, considering human data, could be relevant for prostate cancer.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16123-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16123-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16123-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().