A human monoclonal antibody blocking SARS-CoV-2 infection

Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M. A. Okba, Rien Haperen, Albert D. M. E. Osterhaus, Frank J. M. Kuppeveld, Bart L. Haagmans, Frank Grosveld and Berend-Jan Bosch ()
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Chunyan Wang: Utrecht University
Wentao Li: Utrecht University
Dubravka Drabek: Erasmus Medical Center
Nisreen M. A. Okba: Erasmus Medical Center
Rien Haperen: Erasmus Medical Center
Albert D. M. E. Osterhaus: University of Veterinary Medicine
Frank J. M. Kuppeveld: Utrecht University
Bart L. Haagmans: Erasmus Medical Center
Frank Grosveld: Erasmus Medical Center
Berend-Jan Bosch: Utrecht University

Nature Communications, 2020, vol. 11, issue 1, 1-6

Abstract: Abstract The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

Date: 2020
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DOI: 10.1038/s41467-020-16256-y

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