SIRT1 accelerates the progression of activity-based anorexia

Timothy M. Robinette, Justin W. Nicholatos, Adam B. Francisco, Kayla E. Brooks, Rachel Y. Diao, Sandro Sorbi, Valdo Ricca, Benedetta Nacmias, Miguel A. Brieño-Enríquez and Sergiy Libert ()
Additional contact information
Timothy M. Robinette: University of Pittsburgh School of Medicine
Justin W. Nicholatos: Cornell University
Adam B. Francisco: Cornell University
Kayla E. Brooks: Cornell University
Rachel Y. Diao: Cornell University
Sandro Sorbi: University of Florence
Valdo Ricca: University of Florence
Benedetta Nacmias: University of Florence
Miguel A. Brieño-Enríquez: University of Pittsburgh School of Medicine
Sergiy Libert: Cornell University

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Food consumption is fundamental for life, and eating disorders often result in devastating or life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction of energy intake, leading to lowered body weight, constant fear of gaining weight, and psychological disturbances of body perception. Herein, we demonstrate that SIRT1 inhibition, both genetically and pharmacologically, delays the onset and progression of AN behaviors in activity-based anorexia (ABA) models, while SIRT1 activation accelerates ABA phenotypes. Mechanistically, we suggest that SIRT1 promotes progression of ABA, in part through its interaction with NRF1, leading to suppression of a NMDA receptor subunit Grin2A. Our results suggest that AN may arise from pathological positive feedback loops: voluntary food restriction activates SIRT1, promoting anxiety, hyperactivity, and addiction to starvation, exacerbating the dieting and exercising, thus further activating SIRT1. We propose SIRT1 inhibition can break this cycle and provide a potential therapy for individuals suffering from AN.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16348-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16348-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16348-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().