Human norovirus targets enteroendocrine epithelial cells in the small intestine

Kim Y. Green (), Stuart S. Kaufman, Bianca M. Nagata, Natthawan Chaimongkol, Daniel Y. Kim, Eric A. Levenson, Christine M. Tin, Allison Behrle Yardley, Jordan A. Johnson, Ana Beatriz F. Barletta, Khalid M. Khan, Nada A. Yazigi, Sukanya Subramanian, Sangeetha R. Moturi, Thomas M. Fishbein, Ian N. Moore and Stanislav V. Sosnovtsev
Additional contact information
Kim Y. Green: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Stuart S. Kaufman: MedStar Georgetown Transplant Institute and Georgetown University Medical Center
Bianca M. Nagata: Infectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Natthawan Chaimongkol: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Daniel Y. Kim: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Eric A. Levenson: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Christine M. Tin: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Allison Behrle Yardley: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Jordan A. Johnson: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Ana Beatriz F. Barletta: Mosquito Immunity and Vector Competence Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Khalid M. Khan: MedStar Georgetown Transplant Institute and Georgetown University Medical Center
Nada A. Yazigi: MedStar Georgetown Transplant Institute and Georgetown University Medical Center
Sukanya Subramanian: MedStar Georgetown Transplant Institute and Georgetown University Medical Center
Sangeetha R. Moturi: MedStar Georgetown Transplant Institute and Georgetown University Medical Center
Thomas M. Fishbein: MedStar Georgetown Transplant Institute and Georgetown University Medical Center
Ian N. Moore: Infectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Stanislav V. Sosnovtsev: Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal and ileal tissue from one pediatric intestinal transplant recipient with severe gastroenteritis. Negative-sense viral RNA, a marker of active viral replication, is found predominantly in intestinal epithelial cells, with chromogranin A-positive enteroendocrine cells (EECs) identified as a permissive cell type in this patient. These findings are consistent with the detection of norovirus-positive EECs in the other three immunocompromised patients. Investigation of the signaling pathways induced in EECs that mediate communication between the gut and brain may clarify mechanisms of pathogenesis and lead to the development of in vitro model systems in which to evaluate norovirus vaccines and treatment.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16491-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16491-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16491-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().