Precise capture and dynamic relocation of nanoparticulate biomolecules through dielectrophoretic enhancement by vertical nanogap architectures

Eui-Sang Yu, Hyojin Lee, Sun-Mi Lee, Jiwon Kim, Taehyun Kim, Jongsu Lee, Chulki Kim, Minah Seo, Jae Hun Kim, Young Tae Byun, Seung-Chul Park, Seung-Yeol Lee, Sin-Doo Lee () and Yong-Sang Ryu ()
Additional contact information
Eui-Sang Yu: Korea Institute of Science and Technology
Hyojin Lee: Korea Institute of Science and Technology
Sun-Mi Lee: Korea Institute of Science and Technology
Jiwon Kim: Korea Institute of Science and Technology
Taehyun Kim: Korea Institute of Science and Technology
Jongsu Lee: Korea Institute of Science and Technology
Chulki Kim: Korea Institute of Science and Technology
Minah Seo: Korea Institute of Science and Technology
Jae Hun Kim: Korea Institute of Science and Technology
Young Tae Byun: Korea Institute of Science and Technology
Seung-Chul Park: Korea Institute of Machinery and Materials
Seung-Yeol Lee: Kyungpook National University
Sin-Doo Lee: Seoul National University
Yong-Sang Ryu: Korea Institute of Science and Technology

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorting and accurate positioning the nanoparticulate biomolecules within pre-defined micro/nanostructures is critical, however, it remains a huge hurdle for the realization of practical surface-sensitive biosensors and biochips. A scalable, massive, and non-destructive trapping methodology based on dielectrophoretic forces is highly demanded for assembling nanoparticles and biosensing tools. Herein, we propose a vertical nanogap architecture with an electrode-insulator-electrode stack structure, facilitating the generation of strong dielectrophoretic forces at low voltages, to precisely capture and spatiotemporally manipulate nanoparticles and molecular assemblies, including lipid vesicles and amyloid-beta protofibrils/oligomers. Our vertical nanogap platform, allowing low-voltage nanoparticle captures on optical metasurface designs, provides new opportunities for constructing advanced surface-sensitive optoelectronic sensors.

Date: 2020
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DOI: 10.1038/s41467-020-16630-w

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