Transplacental transmission of SARS-CoV-2 infection

Alexandre J. Vivanti, Christelle Vauloup-Fellous, Sophie Prevot, Veronique Zupan, Cecile Suffee, Jeremy Cao, Alexandra Benachi and Daniele De Luca ()
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Alexandre J. Vivanti: Paris Saclay University Hospitals
Christelle Vauloup-Fellous: Paris Saclay University Hospitals
Sophie Prevot: Paris Saclay University Hospitals, APHP
Veronique Zupan: Paris Saclay University Hospitals
Cecile Suffee: Paris Saclay University Hospitals
Jeremy Cao: Paris Saclay University Hospitals
Alexandra Benachi: Paris Saclay University Hospitals
Daniele De Luca: Paris Saclay University Hospitals

Nature Communications, 2020, vol. 11, issue 1, 1-7

Abstract: Abstract SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.

Date: 2020
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DOI: 10.1038/s41467-020-17436-6

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