The unified myofibrillar matrix for force generation in muscle

T. Bradley Willingham, Yuho Kim, Eric Lindberg, Christopher K. E. Bleck and Brian Glancy ()
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T. Bradley Willingham: National Institutes of Health
Yuho Kim: National Institutes of Health
Eric Lindberg: National Institutes of Health
Christopher K. E. Bleck: National Institutes of Health
Brian Glancy: National Institutes of Health

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Human movement occurs through contraction of the basic unit of the muscle cell, the sarcomere. Sarcomeres have long been considered to be arranged end-to-end in series along the length of the muscle into tube-like myofibrils with many individual, parallel myofibrils comprising the bulk of the muscle cell volume. Here, we demonstrate that striated muscle cells form a continuous myofibrillar matrix linked together by frequently branching sarcomeres. We find that all muscle cells contain highly connected myofibrillar networks though the frequency of sarcomere branching goes down from early to late postnatal development and is higher in slow-twitch than fast-twitch mature muscles. Moreover, we show that the myofibrillar matrix is united across the entire width of the muscle cell both at birth and in mature muscle. We propose that striated muscle force is generated by a singular, mesh-like myofibrillar network rather than many individual, parallel myofibrils.

Date: 2020
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DOI: 10.1038/s41467-020-17579-6

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