Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

David Simon, Koray Tascilar, Gerhard Krönke, Arnd Kleyer, Mario M. Zaiss, Franz Heppt, Christine Meder, Raja Atreya, Entcho Klenske, Peter Dietrich, Abdullah Abdullah, Thorsten Kliem, Giulia Corte, Harriet Morf, Moritz Leppkes, Andreas E. Kremer, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Clara Maier, Axel J. Hueber, Karin Manger, Bernhard Manger, Carola Berking, Matthias Tenbusch, Klaus Überla, Michael Sticherling, Markus F. Neurath and Georg Schett ()
Additional contact information
David Simon: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Koray Tascilar: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Gerhard Krönke: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Arnd Kleyer: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Mario M. Zaiss: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Franz Heppt: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Christine Meder: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Raja Atreya: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Entcho Klenske: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Peter Dietrich: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Abdullah Abdullah: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Thorsten Kliem: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Giulia Corte: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Harriet Morf: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Moritz Leppkes: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Andreas E. Kremer: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Andreas Ramming: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Milena Pachowsky: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Florian Schuch: Rheumatology Clinical Practice Erlangen
Monika Ronneberger: Rheumatology Clinical Practice Erlangen
Stefan Kleinert: Rheumatology Clinical Practice Erlangen
Clara Maier: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Axel J. Hueber: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Karin Manger: Rheumatology Practice Bamberg
Bernhard Manger: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen
Carola Berking: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Matthias Tenbusch: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Klaus Überla: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Michael Sticherling: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Markus F. Neurath: FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen
Georg Schett: Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen

Nature Communications, 2020, vol. 11, issue 1, 1-7

Abstract: Abstract Immune-mediated inflammatory diseases (IMIDs) of the joints, gut and skin are treated with inhibitors of inflammatory cytokines. These cytokines are involved in the pathogenesis of coronavirus disease 2019 (COVID-19). Investigating anti-SARS-CoV-2 antibody responses in IMIDs we observe a reduced incidence of SARS-CoV-2 seroconversion in IMID patients treated with cytokine inhibitors compared to patients receiving no such inhibitors and two healthy control populations, despite similar social exposure. Hence, cytokine inhibitors seem to at least partially protect from SARS-CoV-2 infection.

Date: 2020
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DOI: 10.1038/s41467-020-17703-6

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