Spatially selective manipulation of cells with single-beam acoustical tweezers

Michael Baudoin (), Jean-Louis Thomas, Roudy Al Sahely, Jean-Claude Gerbedoen, Zhixiong Gong, Aude Sivery, Olivier Bou Matar, Nikolay Smagin, Peter Favreau and Alexis Vlandas ()
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Michael Baudoin: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Jean-Louis Thomas: Sorbonne Université, CNRS, Institut des NanoSciences de Paris, INSP
Roudy Al Sahely: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Jean-Claude Gerbedoen: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Zhixiong Gong: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Aude Sivery: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Olivier Bou Matar: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Nikolay Smagin: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Peter Favreau: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD
Alexis Vlandas: Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520—IEMN, SATT NORD

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equivalent power. Yet, these perspectives have so far been hindered by the absence of spatial selectivity of existing acoustical tweezers - i.e., the ability to select and move objects individually - and/or their limited resolution restricting their use to large particle manipulation only and/or finally the limited forces that they could apply. Here, we report precise selective manipulation and positioning of individual human cells in a standard microscopy environment with trapping forces up to ~200 pN without altering their viability. These results are obtained with miniaturized acoustical tweezers combining holography with active materials to synthesize specific wavefields called focused acoustical vortices designed to produce stiff localized traps with reduced acoustic power.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18000-y

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DOI: 10.1038/s41467-020-18000-y

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