Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

Yuqian Qiao, Xiangmei Liu (), Bo Li, Yong Han, Yufeng Zheng, Kelvin Wai Kwok Yeung, Changyi Li, Zhenduo Cui, Yanqin Liang, Zhaoyang Li, Shengli Zhu, Xianbao Wang and Shuilin Wu ()
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Yuqian Qiao: The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University
Xiangmei Liu: Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University
Bo Li: School of Materials Science and Engineering, Xi’an Jiaotong University
Yong Han: School of Materials Science and Engineering, Xi’an Jiaotong University
Yufeng Zheng: Peking University
Kelvin Wai Kwok Yeung: Li Ka Shing Faculty of Medicine, The University of Hong Kong
Changyi Li: Tianjin Medical University
Zhenduo Cui: The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University
Yanqin Liang: The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University
Zhaoyang Li: The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University
Shengli Zhu: The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University
Xianbao Wang: Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University
Shuilin Wu: The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe3O4/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe3O4/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe3O4/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections.

Date: 2020
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DOI: 10.1038/s41467-020-18268-0

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