A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Angkana T. Huang, Bernardo Garcia-Carreras, Matt D. T. Hitchings, Bingyi Yang, Leah C. Katzelnick, Susan M. Rattigan, Brooke A. Borgert, Carlos A. Moreno, Benjamin D. Solomon, Luke Trimmer-Smith, Veronique Etienne, Isabel Rodriguez-Barraquer, Justin Lessler, Henrik Salje, Donald S. Burke, Amy Wesolowski and Derek A. T. Cummings ()
Additional contact information
Angkana T. Huang: University of Florida
Bernardo Garcia-Carreras: University of Florida
Matt D. T. Hitchings: University of Florida
Bingyi Yang: University of Florida
Leah C. Katzelnick: University of Florida
Susan M. Rattigan: University of Florida
Brooke A. Borgert: University of Florida
Carlos A. Moreno: University of Florida
Benjamin D. Solomon: National Human Genome Research Institute, National Institutes of Health
Luke Trimmer-Smith: University of Florida
Veronique Etienne: University of Florida
Isabel Rodriguez-Barraquer: University of California
Justin Lessler: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
Henrik Salje: University of Florida
Donald S. Burke: University of Pittsburgh
Amy Wesolowski: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
Derek A. T. Cummings: University of Florida

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (10)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18450-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18450-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18450-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().