Health and disease markers correlate with gut microbiome composition across thousands of people

Ohad Manor (), Chengzhen L. Dai, Sergey A. Kornilov, Brett Smith, Nathan D. Price, Jennifer C. Lovejoy, Sean M. Gibbons and Andrew T. Magis
Additional contact information
Ohad Manor: Century Therapeutics
Chengzhen L. Dai: Institute for Systems Biology
Sergey A. Kornilov: Institute for Systems Biology
Brett Smith: Institute for Systems Biology
Nathan D. Price: Institute for Systems Biology
Jennifer C. Lovejoy: Institute for Systems Biology
Sean M. Gibbons: Institute for Systems Biology
Andrew T. Magis: Institute for Systems Biology

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Variation in the human gut microbiome can reflect host lifestyle and behaviors and influence disease biomarker levels in the blood. Understanding the relationships between gut microbes and host phenotypes are critical for understanding wellness and disease. Here, we examine associations between the gut microbiota and ~150 host phenotypic features across ~3,400 individuals. We identify major axes of taxonomic variance in the gut and a putative diversity maximum along the Firmicutes-to-Bacteroidetes axis. Our analyses reveal both known and unknown associations between microbiome composition and host clinical markers and lifestyle factors, including host-microbe associations that are composition-specific. These results suggest potential opportunities for targeted interventions that alter the composition of the microbiome to improve host health. By uncovering the interrelationships between host diet and lifestyle factors, clinical blood markers, and the human gut microbiome at the population-scale, our results serve as a roadmap for future studies on host-microbe interactions and interventions.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (10)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18871-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18871-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18871-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().