Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin

Beatrice Dyring-Andersen, Marianne Bengtson Løvendorf, Fabian Coscia, Alberto Santos, Line Bruun Pilgaard Møller, Ana R. Colaço, Lili Niu, Michael Bzorek, Sophia Doll, Jørgen Lock Andersen, Rachael A. Clark, Lone Skov, Marcel B. M. Teunissen and Matthias Mann ()
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Beatrice Dyring-Andersen: Faculty of Health and Medical Sciences, University of Copenhagen
Marianne Bengtson Løvendorf: Aalborg University
Fabian Coscia: Faculty of Health and Medical Sciences, University of Copenhagen
Alberto Santos: Faculty of Health and Medical Sciences, University of Copenhagen
Line Bruun Pilgaard Møller: Faculty of Health and Medical Sciences, University of Copenhagen
Ana R. Colaço: Faculty of Health and Medical Sciences, University of Copenhagen
Lili Niu: Faculty of Health and Medical Sciences, University of Copenhagen
Michael Bzorek: Zealand University Hospital
Sophia Doll: Max Planck Institute of Biochemistry
Jørgen Lock Andersen: Zealand University Hospital
Rachael A. Clark: Brigham and Women’s Hospital and Harvard Medical School
Lone Skov: Herlev and Gentofte Hospital, University of Copenhagen
Marcel B. M. Teunissen: Amsterdam University Medical Centers, location AMC
Matthias Mann: Faculty of Health and Medical Sciences, University of Copenhagen

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically characterized. Here, we combine advanced tissue dissection methods, flow cytometry and state-of-the-art proteomics to describe a spatially-resolved quantitative proteomic atlas of human skin. We quantify 10,701 proteins as a function of their spatial location and cellular origin. The resulting protein atlas and our initial data analyses demonstrate the value of proteomics for understanding cell-type diversity within the skin. We describe the quantitative distribution of structural proteins, known and previously undescribed proteins specific to cellular subsets and those with specialized immunological functions such as cytokines and chemokines. We anticipate that this proteomic atlas of human skin will become an essential community resource for basic and translational research ( https://skin.science/ ).

Date: 2020
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DOI: 10.1038/s41467-020-19383-8

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