Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany

Hendrik Streeck (), Bianca Schulte, Beate M. Kümmerer, Enrico Richter, Tobias Höller, Christine Fuhrmann, Eva Bartok, Ramona Dolscheid-Pommerich, Moritz Berger, Lukas Wessendorf, Monika Eschbach-Bludau, Angelika Kellings, Astrid Schwaiger, Martin Coenen, Per Hoffmann, Birgit Stoffel-Wagner, Markus M. Nöthen, Anna M. Eis-Hübinger, Martin Exner, Ricarda Maria Schmithausen, Matthias Schmid and Gunther Hartmann ()
Additional contact information
Hendrik Streeck: University Hospital, University of Bonn
Bianca Schulte: University Hospital, University of Bonn
Beate M. Kümmerer: University Hospital, University of Bonn
Enrico Richter: University Hospital, University of Bonn
Tobias Höller: University Hospital, University of Bonn
Christine Fuhrmann: University Hospital, University of Bonn
Eva Bartok: German Center for Infection Research (DZIF), Partner Site Bonn-Cologne
Ramona Dolscheid-Pommerich: German Center for Infection Research (DZIF), Partner Site Bonn-Cologne
Moritz Berger: Informatics and Epidemiology, University Hospital, University of Bonn
Lukas Wessendorf: University Hospital, University of Bonn
Monika Eschbach-Bludau: University Hospital, University of Bonn
Angelika Kellings: University Hospital, University of Bonn
Astrid Schwaiger: University Hospital, University of Bonn
Martin Coenen: University Hospital, University of Bonn
Per Hoffmann: University Hospital, University of Bonn
Birgit Stoffel-Wagner: German Center for Infection Research (DZIF), Partner Site Bonn-Cologne
Markus M. Nöthen: University Hospital, University of Bonn
Anna M. Eis-Hübinger: University Hospital, University of Bonn
Martin Exner: University Hospital, University of Bonn
Ricarda Maria Schmithausen: University Hospital, University of Bonn
Matthias Schmid: Informatics and Epidemiology, University Hospital, University of Bonn
Gunther Hartmann: German Center for Infection Research (DZIF), Partner Site Bonn-Cologne

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract A SARS-CoV2 super-spreading event occurred during carnival in a small town in Germany. Due to the rapidly imposed lockdown and its relatively closed community, this town was seen as an ideal model to investigate the infection fatality rate (IFR). Here, a 7-day seroepidemiological observational study was performed to collect information and biomaterials from a random, household-based study population. The number of infections was determined by IgG analyses and PCR testing. We found that of the 919 individuals with evaluable infection status, 15.5% (95% CI:[12.3%; 19.0%]) were infected. This is a fivefold higher rate than the reported cases for this community (3.1%). 22.2% of all infected individuals were asymptomatic. The estimated IFR was 0.36% (95% CI:[0.29%; 0.45%]) for the community and 0.35% [0.28%; 0.45%] when age-standardized to the population of the community. Participation in carnival increased both infection rate (21.3% versus 9.5%, p

Date: 2020
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DOI: 10.1038/s41467-020-19509-y

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