Common diseases alter the physiological age-related blood microRNA profile

Tobias Fehlmann, Benoit Lehallier, Nicholas Schaum, Oliver Hahn, Mustafa Kahraman, Yongping Li, Nadja Grammes, Lars Geffers, Christina Backes, Rudi Balling, Fabian Kern, Rejko Krüger, Frank Lammert, Nicole Ludwig, Benjamin Meder, Bastian Fromm, Walter Maetzler, Daniela Berg, Kathrin Brockmann, Christian Deuschle, Anna-Katharina Thaler, Gerhard W. Eschweiler, Sofiya Milman, Nir Barziliai, Matthias Reichert, Tony Wyss-Coray, Eckart Meese and Andreas Keller ()
Additional contact information
Tobias Fehlmann: Saarland University
Benoit Lehallier: Stanford University
Nicholas Schaum: Stanford University
Oliver Hahn: Stanford University
Mustafa Kahraman: Saarland University
Yongping Li: Saarland University
Nadja Grammes: Saarland University
Lars Geffers: Luxembourg Center for Systems Biomedicine
Christina Backes: Saarland University
Rudi Balling: Luxembourg Center for Systems Biomedicine
Fabian Kern: Saarland University
Rejko Krüger: Luxembourg Center for Systems Biomedicine
Frank Lammert: Saarland University
Nicole Ludwig: Saarland University
Benjamin Meder: University Hospital Heidelberg
Bastian Fromm: Stockholm University
Walter Maetzler: Christian-Albrechts-Universität zu Kiel
Daniela Berg: Christian-Albrechts-Universität zu Kiel
Kathrin Brockmann: TREND study center Tübingen
Christian Deuschle: TREND study center Tübingen
Anna-Katharina Thaler: TREND study center Tübingen
Gerhard W. Eschweiler: University Hospital Tübingen
Sofiya Milman: Albert Einstein College of Medicine
Nir Barziliai: Albert Einstein College of Medicine
Matthias Reichert: Saarland University
Tony Wyss-Coray: Stanford University
Eckart Meese: Saarland University
Andreas Keller: Saarland University

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.

Date: 2020
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DOI: 10.1038/s41467-020-19665-1

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