A droplet microfluidic platform for high-throughput photochemical reaction discovery

Alexandra C. Sun, Daniel J. Steyer, Anthony R. Allen, Emory M. Payne, Robert T. Kennedy () and Corey R. J. Stephenson ()
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Alexandra C. Sun: University of Michigan
Daniel J. Steyer: University of Michigan
Anthony R. Allen: University of Michigan
Emory M. Payne: University of Michigan
Robert T. Kennedy: University of Michigan
Corey R. J. Stephenson: University of Michigan

Nature Communications, 2020, vol. 11, issue 1, 1-6

Abstract: Abstract The implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating discovery scale vial-based batch reactions to continuous flow scale-up conditions. Herein we report the development of a droplet microfluidic platform, which enables high-throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries. This platform allows for enhanced material efficiency, as reactions can be performed on picomole scale. Furthermore, high-throughput data collection via on-line ESI mass spectrometry facilitates the rapid analysis of individual, nanoliter-sized reaction droplets at acquisition rates of 0.3 samples/s. We envision this high-throughput screening platform to expand upon the robust capabilities and impact of photochemical reactions in drug discovery and development.

Date: 2020
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DOI: 10.1038/s41467-020-19926-z

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