Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Jean-Baptiste Cavin, Alexandra Willemetz, Johanne Beyec, Aurélie Sannier, Samira Benadda, Anne-Laure Pelletier, Muriel Hourseau, Thibaut Léger, Bastien Morlet, Anne Couvelard, Younes Anini, Simon Msika, Jean-Pierre Marmuse, Sévérine Ledoux, Maude Gall () and André Bado ()
Additional contact information
Lara Ribeiro-Parenti: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Anne-Charlotte Jarry: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Jean-Baptiste Cavin: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Alexandra Willemetz: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Johanne Beyec: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Aurélie Sannier: Department of Pathology Bichat Hospital, AP-HP
Samira Benadda: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Anne-Laure Pelletier: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Muriel Hourseau: Department of Pathology Bichat Hospital, AP-HP
Thibaut Léger: Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS
Bastien Morlet: Université de Paris, Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, CNRS
Anne Couvelard: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Younes Anini: Dalhousie University, IWK Health Centre
Simon Msika: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Jean-Pierre Marmuse: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Sévérine Ledoux: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
Maude Gall: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation
André Bado: Université de Paris, Inserm U1149, Centre de Recherche sur l’inflammation

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-20301-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20301-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-20301-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().