Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence

Sebastian R. Schreglmann, David Wang, Robert L. Peach, Junheng Li, Xu Zhang, Anna Latorre, Edward Rhodes, Emanuele Panella, Antonino M. Cassara, Edward S. Boyden, Mauricio Barahona, Sabato Santaniello, John Rothwell, Kailash P. Bhatia () and Nir Grossman ()
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Sebastian R. Schreglmann: Queen Square, University College London (UCL)
David Wang: Massachussetts Institute of Technology (MIT)
Robert L. Peach: Imperial College London
Junheng Li: Imperial College London
Xu Zhang: University of Connecticut
Anna Latorre: Queen Square, University College London (UCL)
Edward Rhodes: Imperial College London
Emanuele Panella: Imperial College London
Antonino M. Cassara: IT’IS Foundation for Research on Information Technologies in Society
Edward S. Boyden: MIT
Mauricio Barahona: Imperial College London
Sabato Santaniello: University of Connecticut
John Rothwell: Queen Square, University College London (UCL)
Kailash P. Bhatia: Queen Square, University College London (UCL)
Nir Grossman: Imperial College London

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult movement disorder, can be transiently suppressed via transcranial electrical stimulation of the cerebellum phase-locked to the tremor. The tremor suppression is sustained shortly after the end of the stimulation and can be phenomenologically predicted. Finally, we use feature-based statistical-learning and neurophysiological-modelling to show that the suppression of ET is mechanistically attributed to a disruption of the temporal coherence of the aberrant oscillations in the olivocerebellar loop, thus establishing its causal role. The suppression of aberrant neural oscillation via phase-locked driven disruption of temporal coherence may in the future represent a powerful neuromodulatory strategy to treat brain disorders.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20581-7

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DOI: 10.1038/s41467-020-20581-7

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